Molecular profiling of individual FDA-approved clinical drugs identifies modulators of nonsense-mediated mRNA decay

Nonsense-mediated mRNA decay (NMD) degrades transcripts with premature stop codons. Given the prevalence of nonsense single nucleotide polymorphisms (SNPs) in the general population, it is urgent to catalog the effects of clinically approved drugs on NMD activity: any interference could alter the ex...

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Detalles Bibliográficos
Autores principales: Zhao, Jingrong, Li, Zhelin, Puri, Ruchira, Liu, Kelvin, Nunez, Israel, Chen, Liang, Zheng, Sika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718828/
https://www.ncbi.nlm.nih.gov/pubmed/35024243
http://dx.doi.org/10.1016/j.omtn.2021.12.003

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