Invasive phenotype in triple negative breast cancer is inhibited by blocking SIN3A–PF1 interaction through KLF9 mediated repression of ITGA6 and ITGB1

SIN3A, a scaffold protein has regulatory functions in tumor biology. Through its Paired amphipathic helix (PAH2) domain, SIN3A interacts with PHF12 (PF1), a protein with SIN3 interaction domain (SID) that forms a complex with MRG15 and KDM5A/B. These components are often overexpressed in cancer. In...

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Detalles Bibliográficos
Autores principales: Kadamb, Rama, Leibovitch, Boris A, Farias, Eduardo F, Dahiya, Nisha, Suryawanshi, Hemant, Bansal, Nidhi, Waxman, Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718897/
https://www.ncbi.nlm.nih.gov/pubmed/34968869
http://dx.doi.org/10.1016/j.tranon.2021.101320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718897/
https://www.ncbi.nlm.nih.gov/pubmed/34968869
http://dx.doi.org/10.1016/j.tranon.2021.101320

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