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Quantitative Electroencephalogram Standardization: A Sex- and Age-Differentiated Normative Database
We describe the utility of a standardized index (Z-score) in quantitative EEG (QEEG) capable of when referenced to a resting-state, sex- and age-differentiated QEEG normative database (ISB-NormDB). Our ISB-NormDB comprises data for 1,289 subjects (553 males, 736 females) ages 4.5 to 81 years that me...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718919/ https://www.ncbi.nlm.nih.gov/pubmed/34975376 http://dx.doi.org/10.3389/fnins.2021.766781 |
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author | Ko, Juhee Park, Ukeob Kim, Daekeun Kang, Seung Wan |
author_facet | Ko, Juhee Park, Ukeob Kim, Daekeun Kang, Seung Wan |
author_sort | Ko, Juhee |
collection | PubMed |
description | We describe the utility of a standardized index (Z-score) in quantitative EEG (QEEG) capable of when referenced to a resting-state, sex- and age-differentiated QEEG normative database (ISB-NormDB). Our ISB-NormDB comprises data for 1,289 subjects (553 males, 736 females) ages 4.5 to 81 years that met strict normative data criteria. A de-noising process allowed stratification based on QEEG variability between normal healthy men and women at various age ranges. The ISB-NormDB data set that is stratified by sex provides a unique, highly accurate ISB-NormDB model (ISB-NormDB: ISB-NormDB-Male, ISB-NormDB-Female). To evaluate the trends and accuracy of the ISB-NormDB, we used actual data to compare Z-scores obtained through the ISB-NormDB with those obtained through a traditional QEEG normative database to confirm that basic trends are maintained in most bands and are sensitive to abnormal test data. Finally, we demonstrate the value of our standardized index of QEEG, and highlight it’s capacity to minimize the confounding variables of sex and age in any analysis. |
format | Online Article Text |
id | pubmed-8718919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87189192022-01-01 Quantitative Electroencephalogram Standardization: A Sex- and Age-Differentiated Normative Database Ko, Juhee Park, Ukeob Kim, Daekeun Kang, Seung Wan Front Neurosci Neuroscience We describe the utility of a standardized index (Z-score) in quantitative EEG (QEEG) capable of when referenced to a resting-state, sex- and age-differentiated QEEG normative database (ISB-NormDB). Our ISB-NormDB comprises data for 1,289 subjects (553 males, 736 females) ages 4.5 to 81 years that met strict normative data criteria. A de-noising process allowed stratification based on QEEG variability between normal healthy men and women at various age ranges. The ISB-NormDB data set that is stratified by sex provides a unique, highly accurate ISB-NormDB model (ISB-NormDB: ISB-NormDB-Male, ISB-NormDB-Female). To evaluate the trends and accuracy of the ISB-NormDB, we used actual data to compare Z-scores obtained through the ISB-NormDB with those obtained through a traditional QEEG normative database to confirm that basic trends are maintained in most bands and are sensitive to abnormal test data. Finally, we demonstrate the value of our standardized index of QEEG, and highlight it’s capacity to minimize the confounding variables of sex and age in any analysis. Frontiers Media S.A. 2021-12-17 /pmc/articles/PMC8718919/ /pubmed/34975376 http://dx.doi.org/10.3389/fnins.2021.766781 Text en Copyright © 2021 Ko, Park, Kim and Kang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Ko, Juhee Park, Ukeob Kim, Daekeun Kang, Seung Wan Quantitative Electroencephalogram Standardization: A Sex- and Age-Differentiated Normative Database |
title | Quantitative Electroencephalogram Standardization: A Sex- and Age-Differentiated Normative Database |
title_full | Quantitative Electroencephalogram Standardization: A Sex- and Age-Differentiated Normative Database |
title_fullStr | Quantitative Electroencephalogram Standardization: A Sex- and Age-Differentiated Normative Database |
title_full_unstemmed | Quantitative Electroencephalogram Standardization: A Sex- and Age-Differentiated Normative Database |
title_short | Quantitative Electroencephalogram Standardization: A Sex- and Age-Differentiated Normative Database |
title_sort | quantitative electroencephalogram standardization: a sex- and age-differentiated normative database |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718919/ https://www.ncbi.nlm.nih.gov/pubmed/34975376 http://dx.doi.org/10.3389/fnins.2021.766781 |
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