Cytotoxic tau released from lung microvascular endothelial cells upon infection with Pseudomonas aeruginosa promotes neuronal tauopathy

Patients who recover from nosocomial pneumonia oftentimes exhibit long-lasting cognitive impairment comparable with what is observed in Alzheimer’s disease patients. We previously hypothesized that the lung endothelium contributes to infection-related neurocognitive dysfunction, because bacteria-exp...

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Detalles Bibliográficos
Autores principales: Choi, Chung-Sik, Gwin, Meredith, Voth, Sarah, Kolb, Claire, Zhou, Chun, Nelson, Amy R., deWeever, Althea, Koloteva, Anna, Annamdevula, Naga S., Murphy, James M., Wagener, Brant M., Pittet, Jean-Francois, Lim, Ssang-Taek S., Balczon, Ron, Stevens, Troy, Lin, Mike T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718960/
https://www.ncbi.nlm.nih.gov/pubmed/34896150
http://dx.doi.org/10.1016/j.jbc.2021.101482

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