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Clinical tools and biomarkers to predict preeclampsia

Preeclampsia is pregnancy-specific, and significantly contributes to maternal, and perinatal morbidity and mortality worldwide. An effective predictive test for preeclampsia would facilitate early diagnosis, targeted surveillance and timely delivery; however limited options currently exist. A first-...

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Autores principales: MacDonald, Teresa M, Walker, Susan P, Hannan, Natalie J, Tong, Stephen, Kaitu'u-Lino, Tu'uhevaha J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718967/
https://www.ncbi.nlm.nih.gov/pubmed/34954654
http://dx.doi.org/10.1016/j.ebiom.2021.103780
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author MacDonald, Teresa M
Walker, Susan P
Hannan, Natalie J
Tong, Stephen
Kaitu'u-Lino, Tu'uhevaha J
author_facet MacDonald, Teresa M
Walker, Susan P
Hannan, Natalie J
Tong, Stephen
Kaitu'u-Lino, Tu'uhevaha J
author_sort MacDonald, Teresa M
collection PubMed
description Preeclampsia is pregnancy-specific, and significantly contributes to maternal, and perinatal morbidity and mortality worldwide. An effective predictive test for preeclampsia would facilitate early diagnosis, targeted surveillance and timely delivery; however limited options currently exist. A first-trimester screening algorithm has been developed and validated to predict preterm preeclampsia, with poor utility for term disease, where the greatest burden lies. Biomarkers such as sFlt-1 and placental growth factor are also now being used clinically in cases of suspected preterm preeclampsia; their high negative predictive value enables confident exclusion of disease in women with normal results, but sensitivity is modest. There has been a concerted effort to identify potential novel biomarkers that might improve prediction. These largely originate from organs involved in preeclampsia's pathogenesis, including placental, cardiovascular and urinary biomarkers. This review outlines the clinical imperative for an effective test and those already in use and summarises current preeclampsia biomarker research.
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spelling pubmed-87189672022-01-07 Clinical tools and biomarkers to predict preeclampsia MacDonald, Teresa M Walker, Susan P Hannan, Natalie J Tong, Stephen Kaitu'u-Lino, Tu'uhevaha J EBioMedicine Review Preeclampsia is pregnancy-specific, and significantly contributes to maternal, and perinatal morbidity and mortality worldwide. An effective predictive test for preeclampsia would facilitate early diagnosis, targeted surveillance and timely delivery; however limited options currently exist. A first-trimester screening algorithm has been developed and validated to predict preterm preeclampsia, with poor utility for term disease, where the greatest burden lies. Biomarkers such as sFlt-1 and placental growth factor are also now being used clinically in cases of suspected preterm preeclampsia; their high negative predictive value enables confident exclusion of disease in women with normal results, but sensitivity is modest. There has been a concerted effort to identify potential novel biomarkers that might improve prediction. These largely originate from organs involved in preeclampsia's pathogenesis, including placental, cardiovascular and urinary biomarkers. This review outlines the clinical imperative for an effective test and those already in use and summarises current preeclampsia biomarker research. Elsevier 2021-12-23 /pmc/articles/PMC8718967/ /pubmed/34954654 http://dx.doi.org/10.1016/j.ebiom.2021.103780 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
MacDonald, Teresa M
Walker, Susan P
Hannan, Natalie J
Tong, Stephen
Kaitu'u-Lino, Tu'uhevaha J
Clinical tools and biomarkers to predict preeclampsia
title Clinical tools and biomarkers to predict preeclampsia
title_full Clinical tools and biomarkers to predict preeclampsia
title_fullStr Clinical tools and biomarkers to predict preeclampsia
title_full_unstemmed Clinical tools and biomarkers to predict preeclampsia
title_short Clinical tools and biomarkers to predict preeclampsia
title_sort clinical tools and biomarkers to predict preeclampsia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718967/
https://www.ncbi.nlm.nih.gov/pubmed/34954654
http://dx.doi.org/10.1016/j.ebiom.2021.103780
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