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RQC helical hairpin in Bloom's syndrome helicase regulates DNA unwinding by dynamically intercepting nascent nucleotides

The RecQ family of helicases are important for maintenance of genomic integrity. Although functions of constructive subdomains of this family of helicases have been extensively studied, the helical hairpin (HH) in the RecQ-C-terminal domain (RQC) has been underappreciated and remains poorly understo...

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Detalles Bibliográficos
Autores principales: Ma, Jianbing, Xu, Chunhua, Li, Jinghua, Hou, Xi-Miao, Da, Lin-Tai, Jia, Qi, Huang, Xingyuan, Yu, Jin, Xi, Xuguang, Lu, Ying, Li, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718986/
https://www.ncbi.nlm.nih.gov/pubmed/35005551
http://dx.doi.org/10.1016/j.isci.2021.103606