Strategies for Articular Cartilage Repair and Regeneration

Articular cartilage is an avascular tissue, with limited ability to repair and self-renew. Defects in articular cartilage can induce debilitating degenerative joint diseases such as osteoarthritis. Currently, clinical treatments have limited ability to repair, for they often result in the formation...

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Detalles Bibliográficos
Autores principales: Liu, Yanxi, Shah, Karan M., Luo, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719005/
https://www.ncbi.nlm.nih.gov/pubmed/34976967
http://dx.doi.org/10.3389/fbioe.2021.770655
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author Liu, Yanxi
Shah, Karan M.
Luo, Jian
author_facet Liu, Yanxi
Shah, Karan M.
Luo, Jian
author_sort Liu, Yanxi
collection PubMed
description Articular cartilage is an avascular tissue, with limited ability to repair and self-renew. Defects in articular cartilage can induce debilitating degenerative joint diseases such as osteoarthritis. Currently, clinical treatments have limited ability to repair, for they often result in the formation of mechanically inferior cartilage. In this review, we discuss the factors that affect cartilage homeostasis and function, and describe the emerging regenerative approaches that are informing the future treatment options.
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spelling pubmed-87190052022-01-01 Strategies for Articular Cartilage Repair and Regeneration Liu, Yanxi Shah, Karan M. Luo, Jian Front Bioeng Biotechnol Bioengineering and Biotechnology Articular cartilage is an avascular tissue, with limited ability to repair and self-renew. Defects in articular cartilage can induce debilitating degenerative joint diseases such as osteoarthritis. Currently, clinical treatments have limited ability to repair, for they often result in the formation of mechanically inferior cartilage. In this review, we discuss the factors that affect cartilage homeostasis and function, and describe the emerging regenerative approaches that are informing the future treatment options. Frontiers Media S.A. 2021-12-17 /pmc/articles/PMC8719005/ /pubmed/34976967 http://dx.doi.org/10.3389/fbioe.2021.770655 Text en Copyright © 2021 Liu, Shah and Luo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Liu, Yanxi
Shah, Karan M.
Luo, Jian
Strategies for Articular Cartilage Repair and Regeneration
title Strategies for Articular Cartilage Repair and Regeneration
title_full Strategies for Articular Cartilage Repair and Regeneration
title_fullStr Strategies for Articular Cartilage Repair and Regeneration
title_full_unstemmed Strategies for Articular Cartilage Repair and Regeneration
title_short Strategies for Articular Cartilage Repair and Regeneration
title_sort strategies for articular cartilage repair and regeneration
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719005/
https://www.ncbi.nlm.nih.gov/pubmed/34976967
http://dx.doi.org/10.3389/fbioe.2021.770655
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AT shahkaranm strategiesforarticularcartilagerepairandregeneration
AT luojian strategiesforarticularcartilagerepairandregeneration

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