Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cells via regulation of the p53-checkpoint pathway

Hematopoietic stem cells (HSC) are dominantly quiescent under homeostasis, which is a key mechanism of maintaining the HSC pool for life-long hematopoiesis. Dormant HSC are poised to be immediately activated in certain conditions and can return to quiescence after homeostasis has been regained. At p...

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Detalles Bibliográficos
Autores principales: Wang, Tongjie, Xia, Chengxiang, Weng, Qitong, Wang, Kaitao, Dong, Yong, Hao, Sha, Dong, Fang, Liu, Xiaofei, Liu, Lijuan, Geng, Yang, Guan, Yuxian, Du, Juan, Cheng, Tao, Cheng, Hui, Wang, Jinyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719103/
https://www.ncbi.nlm.nih.gov/pubmed/33299232
http://dx.doi.org/10.3324/haematol.2019.239186

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