The DEXA-CORT trial: study protocol of a randomised placebo-controlled trial of hydrocortisone in patients with brain tumour on the prevention of neuropsychiatric adverse effects caused by perioperative dexamethasone

INTRODUCTION: The synthetic glucocorticoid dexamethasone can induce serious neuropsychiatric adverse effects. Dexamethasone activates the glucocorticoid receptor (GR) but, unlike endogenous cortisol, not the mineralocorticoid receptor (MR). Moreover, dexamethasone suppresses cortisol production, the...

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Detalles Bibliográficos
Autores principales: Koning, Anne-Sophie C A M, Satoer, Djaina D, Vinkers, Christiaan H, Zamanipoor Najafabadi, Amir H, Biermasz, Nienke R, Nandoe Tewarie, Rishi D S, Moojen, Wouter A, van Rossum, Elisabeth F C, Dirven, Clemens M F, Pereira, Alberto M, van Furth, Wouter R, Meijer, Onno C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719188/
https://www.ncbi.nlm.nih.gov/pubmed/37057711
http://dx.doi.org/10.1136/bmjopen-2021-054405

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