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Overexpression of the PPAR-γ protein in primary Ta/T1 non-muscle-invasive urothelial carcinoma

Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a well-known nuclear receptor that is activated in the nucleus to regulate several transcription factors. Its expression patterns have been examined in various types of cancer. The present study investigated the expression patterns of PPAR-γ i...

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Autores principales: Tanaka, Shinichi, Tokuhara, Yasunori, Hosokawa, Sho, Ohsaki, Hiroyuki, Morinishi, Tatsuya, Yamamoto, Tamami, Teramoto, Norihiro, Hirakawa, Eiichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719252/
https://www.ncbi.nlm.nih.gov/pubmed/34984103
http://dx.doi.org/10.3892/mco.2021.2469
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author Tanaka, Shinichi
Tokuhara, Yasunori
Hosokawa, Sho
Ohsaki, Hiroyuki
Morinishi, Tatsuya
Yamamoto, Tamami
Teramoto, Norihiro
Hirakawa, Eiichiro
author_facet Tanaka, Shinichi
Tokuhara, Yasunori
Hosokawa, Sho
Ohsaki, Hiroyuki
Morinishi, Tatsuya
Yamamoto, Tamami
Teramoto, Norihiro
Hirakawa, Eiichiro
author_sort Tanaka, Shinichi
collection PubMed
description Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a well-known nuclear receptor that is activated in the nucleus to regulate several transcription factors. Its expression patterns have been examined in various types of cancer. The present study investigated the expression patterns of PPAR-γ in non-muscle-invasive urothelial carcinoma. The expression rates of PPAR-γ, p53 and Ki-67 were compared to determine whether PPAR-γ may be considered as an immunobiomarker for bladder cancer. The intensity and extent of PPAR-γ expression were evaluated in 79 cases of non-muscle-invasive urothelial carcinoma (30 cases of papillary carcinoma low-grade, 30 cases of high-grade and 19 cases of carcinoma in situ) and 30 non-malignant cases. The nuclear overexpression of PPAR-γ was frequently observed in non-muscle-invasive urothelial carcinoma (63/79 cases) but was rarely detected in non-malignant cases (2/30 cases). The histological proliferation types of non-muscle-invasive urothelial carcinoma revealed that PPAR-γ was more frequently overexpressed in papillary carcinoma (54/60 cases) than in carcinoma in situ (9/19 cases). Immunohistochemical staining demonstrated that PPAR-γ was more useful as an immunobiomarker than p53 or Ki-67 (diagnostic odds ratios; 55.13, 16.82 and 11.13, respectively). In summary, this study demonstrated that the expression patterns of PPAR-γ were associated with histological proliferation type and that PPAR-γ was expressed in the nuclei of papillary carcinoma cells. These findings suggested that immunohistochemical staining for PPAR-γ may be used to comprehensively detect non-muscle-invasive urothelial carcinoma.
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spelling pubmed-87192522022-01-03 Overexpression of the PPAR-γ protein in primary Ta/T1 non-muscle-invasive urothelial carcinoma Tanaka, Shinichi Tokuhara, Yasunori Hosokawa, Sho Ohsaki, Hiroyuki Morinishi, Tatsuya Yamamoto, Tamami Teramoto, Norihiro Hirakawa, Eiichiro Mol Clin Oncol Articles Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a well-known nuclear receptor that is activated in the nucleus to regulate several transcription factors. Its expression patterns have been examined in various types of cancer. The present study investigated the expression patterns of PPAR-γ in non-muscle-invasive urothelial carcinoma. The expression rates of PPAR-γ, p53 and Ki-67 were compared to determine whether PPAR-γ may be considered as an immunobiomarker for bladder cancer. The intensity and extent of PPAR-γ expression were evaluated in 79 cases of non-muscle-invasive urothelial carcinoma (30 cases of papillary carcinoma low-grade, 30 cases of high-grade and 19 cases of carcinoma in situ) and 30 non-malignant cases. The nuclear overexpression of PPAR-γ was frequently observed in non-muscle-invasive urothelial carcinoma (63/79 cases) but was rarely detected in non-malignant cases (2/30 cases). The histological proliferation types of non-muscle-invasive urothelial carcinoma revealed that PPAR-γ was more frequently overexpressed in papillary carcinoma (54/60 cases) than in carcinoma in situ (9/19 cases). Immunohistochemical staining demonstrated that PPAR-γ was more useful as an immunobiomarker than p53 or Ki-67 (diagnostic odds ratios; 55.13, 16.82 and 11.13, respectively). In summary, this study demonstrated that the expression patterns of PPAR-γ were associated with histological proliferation type and that PPAR-γ was expressed in the nuclei of papillary carcinoma cells. These findings suggested that immunohistochemical staining for PPAR-γ may be used to comprehensively detect non-muscle-invasive urothelial carcinoma. D.A. Spandidos 2022-02 2021-12-16 /pmc/articles/PMC8719252/ /pubmed/34984103 http://dx.doi.org/10.3892/mco.2021.2469 Text en Copyright: © Tanaka et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Tanaka, Shinichi
Tokuhara, Yasunori
Hosokawa, Sho
Ohsaki, Hiroyuki
Morinishi, Tatsuya
Yamamoto, Tamami
Teramoto, Norihiro
Hirakawa, Eiichiro
Overexpression of the PPAR-γ protein in primary Ta/T1 non-muscle-invasive urothelial carcinoma
title Overexpression of the PPAR-γ protein in primary Ta/T1 non-muscle-invasive urothelial carcinoma
title_full Overexpression of the PPAR-γ protein in primary Ta/T1 non-muscle-invasive urothelial carcinoma
title_fullStr Overexpression of the PPAR-γ protein in primary Ta/T1 non-muscle-invasive urothelial carcinoma
title_full_unstemmed Overexpression of the PPAR-γ protein in primary Ta/T1 non-muscle-invasive urothelial carcinoma
title_short Overexpression of the PPAR-γ protein in primary Ta/T1 non-muscle-invasive urothelial carcinoma
title_sort overexpression of the ppar-γ protein in primary ta/t1 non-muscle-invasive urothelial carcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719252/
https://www.ncbi.nlm.nih.gov/pubmed/34984103
http://dx.doi.org/10.3892/mco.2021.2469
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