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The Management and Alternative Therapies for Comorbid Sleep Disorders in Epilepsy
BACKGROUND: There is a complex and interactive relationship between sleep and epilepsy. Sleep disorders are common in patients with epilepsy, and methods for managing sleep disorders in patients with epilepsy are limited. OBJECTIVE: This review addresses the relationship among sleep, sleep disorders...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Bentham Science Publishers
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719297/ https://www.ncbi.nlm.nih.gov/pubmed/33380304 http://dx.doi.org/10.2174/1570159X19666201230142716 |
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author | Peng, Weifeng Ding, Jing Wang, Xin |
author_facet | Peng, Weifeng Ding, Jing Wang, Xin |
author_sort | Peng, Weifeng |
collection | PubMed |
description | BACKGROUND: There is a complex and interactive relationship between sleep and epilepsy. Sleep disorders are common in patients with epilepsy, and methods for managing sleep disorders in patients with epilepsy are limited. OBJECTIVE: This review addresses the relationship among sleep, sleep disorders, and epilepsy, focusing on the management of sleep disorders in epilepsy, including some complementary and alternative therapies. METHODS: The terms related to “sleep” and “epilepsy” were searched in “Pubmed” and “Cochrane Library”. RESULTS: Sleep stages differently affect both seizures and interictal epileptiform discharges. Seizures disrupt sleep architecture greatly, especially when occurring during sleep in the night. Insomnia and obstructive sleep apnea (OSA) are the most frequent types of comorbid sleep disorders in patients with epilepsy. Pharmacological agents with both anti-convulsant and sedative effects are the priorities for comorbid sleep disorders in epilepsy. Continuous positive airway pressure (CPAP) therapy is the most effective non-pharmacological method to improve OSA and reduce seizures. Complementary and alternative therapies such as Chinese traditional medicine, cognitive behavioral therapy, meditation, yoga, neurofeedback, and acupuncture may have benefits in reducing seizures and improving sleep quality simultaneously by alleviating stress and seizure triggers; however, evidence-based therapies are still deficient. CONCLUSION: Management of sleep disorders in patients with epilepsy is challenging. Large-scale randomized controlled clinical trials are in demand to guide the treatments in the future. |
format | Online Article Text |
id | pubmed-8719297 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-87192972022-02-11 The Management and Alternative Therapies for Comorbid Sleep Disorders in Epilepsy Peng, Weifeng Ding, Jing Wang, Xin Curr Neuropharmacol Article BACKGROUND: There is a complex and interactive relationship between sleep and epilepsy. Sleep disorders are common in patients with epilepsy, and methods for managing sleep disorders in patients with epilepsy are limited. OBJECTIVE: This review addresses the relationship among sleep, sleep disorders, and epilepsy, focusing on the management of sleep disorders in epilepsy, including some complementary and alternative therapies. METHODS: The terms related to “sleep” and “epilepsy” were searched in “Pubmed” and “Cochrane Library”. RESULTS: Sleep stages differently affect both seizures and interictal epileptiform discharges. Seizures disrupt sleep architecture greatly, especially when occurring during sleep in the night. Insomnia and obstructive sleep apnea (OSA) are the most frequent types of comorbid sleep disorders in patients with epilepsy. Pharmacological agents with both anti-convulsant and sedative effects are the priorities for comorbid sleep disorders in epilepsy. Continuous positive airway pressure (CPAP) therapy is the most effective non-pharmacological method to improve OSA and reduce seizures. Complementary and alternative therapies such as Chinese traditional medicine, cognitive behavioral therapy, meditation, yoga, neurofeedback, and acupuncture may have benefits in reducing seizures and improving sleep quality simultaneously by alleviating stress and seizure triggers; however, evidence-based therapies are still deficient. CONCLUSION: Management of sleep disorders in patients with epilepsy is challenging. Large-scale randomized controlled clinical trials are in demand to guide the treatments in the future. Bentham Science Publishers 2021-08-11 2021-08-11 /pmc/articles/PMC8719297/ /pubmed/33380304 http://dx.doi.org/10.2174/1570159X19666201230142716 Text en © 2021 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Peng, Weifeng Ding, Jing Wang, Xin The Management and Alternative Therapies for Comorbid Sleep Disorders in Epilepsy |
title | The Management and Alternative Therapies for Comorbid Sleep Disorders in Epilepsy |
title_full | The Management and Alternative Therapies for Comorbid Sleep Disorders in Epilepsy |
title_fullStr | The Management and Alternative Therapies for Comorbid Sleep Disorders in Epilepsy |
title_full_unstemmed | The Management and Alternative Therapies for Comorbid Sleep Disorders in Epilepsy |
title_short | The Management and Alternative Therapies for Comorbid Sleep Disorders in Epilepsy |
title_sort | management and alternative therapies for comorbid sleep disorders in epilepsy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719297/ https://www.ncbi.nlm.nih.gov/pubmed/33380304 http://dx.doi.org/10.2174/1570159X19666201230142716 |
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