Novelty‐like activation of locus coeruleus protects against deleterious human pretangle tau effects while stress‐inducing activation worsens its effects

The earliest abnormality associated with Alzheimer's disease (AD) is the presence of persistently phosphorylated pretangle tau in locus coeruleus (LC) neurons. LC neuron numbers and fiber density are positive predictors of cognition prior to death. Using an animal model of LC pretangle tau, we...

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Detalles Bibliográficos
Autores principales: Omoluabi, Tamunotonye, Torraville, Sarah E., Maziar, Aida, Ghosh, Abhinaba, Power, Kyron D., Reinhardt, Camila, Harley, Carolyn W., Yuan, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Alternate Format Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719346/
https://www.ncbi.nlm.nih.gov/pubmed/35005208
http://dx.doi.org/10.1002/trc2.12231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719346/
https://www.ncbi.nlm.nih.gov/pubmed/35005208
http://dx.doi.org/10.1002/trc2.12231

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