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What is the impact of microvascular complications of diabetes on severe COVID-19?

Evidence suggests severe coronavirus disease-19 (COVID-19) infection is characterised by pulmonary and systemic microvasculature dysfunction, specifically, acute endothelial injury, hypercoagulation and increased capillary permeability. Diabetes, which is also characterised by vascular injury in its...

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Detalles Bibliográficos
Autores principales: Basra, Ruman, Whyte, Martin, Karalliedde, Janaka, Vas, Prashanth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719364/
https://www.ncbi.nlm.nih.gov/pubmed/34979154
http://dx.doi.org/10.1016/j.mvr.2021.104310
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author Basra, Ruman
Whyte, Martin
Karalliedde, Janaka
Vas, Prashanth
author_facet Basra, Ruman
Whyte, Martin
Karalliedde, Janaka
Vas, Prashanth
author_sort Basra, Ruman
collection PubMed
description Evidence suggests severe coronavirus disease-19 (COVID-19) infection is characterised by pulmonary and systemic microvasculature dysfunction, specifically, acute endothelial injury, hypercoagulation and increased capillary permeability. Diabetes, which is also characterised by vascular injury in itself, confers an increased risk of adverse COVID-19 outcomes. It has been suggested that pre-existing endothelial dysfunction and microvascular disease in diabetes will exacerbate the vascular insults associated with COVID-19 and thus lead to increased severity of COVID-19 infection. In this article, we evaluate the current evidence exploring the impact of microvascular complications, in the form of diabetic retinopathy and nephropathy, in individuals with COVID-19 and diabetes. Future insights gained from exploring the microvascular injury patterns and clinical outcomes may come to influence care delivery algorithms for either of these conditions.
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spelling pubmed-87193642022-01-03 What is the impact of microvascular complications of diabetes on severe COVID-19? Basra, Ruman Whyte, Martin Karalliedde, Janaka Vas, Prashanth Microvasc Res Article Evidence suggests severe coronavirus disease-19 (COVID-19) infection is characterised by pulmonary and systemic microvasculature dysfunction, specifically, acute endothelial injury, hypercoagulation and increased capillary permeability. Diabetes, which is also characterised by vascular injury in itself, confers an increased risk of adverse COVID-19 outcomes. It has been suggested that pre-existing endothelial dysfunction and microvascular disease in diabetes will exacerbate the vascular insults associated with COVID-19 and thus lead to increased severity of COVID-19 infection. In this article, we evaluate the current evidence exploring the impact of microvascular complications, in the form of diabetic retinopathy and nephropathy, in individuals with COVID-19 and diabetes. Future insights gained from exploring the microvascular injury patterns and clinical outcomes may come to influence care delivery algorithms for either of these conditions. Elsevier Inc. 2022-03 2021-12-31 /pmc/articles/PMC8719364/ /pubmed/34979154 http://dx.doi.org/10.1016/j.mvr.2021.104310 Text en © 2022 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Basra, Ruman
Whyte, Martin
Karalliedde, Janaka
Vas, Prashanth
What is the impact of microvascular complications of diabetes on severe COVID-19?
title What is the impact of microvascular complications of diabetes on severe COVID-19?
title_full What is the impact of microvascular complications of diabetes on severe COVID-19?
title_fullStr What is the impact of microvascular complications of diabetes on severe COVID-19?
title_full_unstemmed What is the impact of microvascular complications of diabetes on severe COVID-19?
title_short What is the impact of microvascular complications of diabetes on severe COVID-19?
title_sort what is the impact of microvascular complications of diabetes on severe covid-19?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719364/
https://www.ncbi.nlm.nih.gov/pubmed/34979154
http://dx.doi.org/10.1016/j.mvr.2021.104310
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