Biologic TNF-α inhibitors reduce microgliosis, neuronal loss, and tau phosphorylation in a transgenic mouse model of tauopathy

BACKGROUND: Tumor necrosis factor-α (TNF-α) plays a central role in Alzheimer’s disease (AD) pathology, making biologic TNF-α inhibitors (TNFIs), including etanercept, viable therapeutics for AD. The protective effects of biologic TNFIs on AD hallmark pathology (Aβ deposition and tau pathology) have...

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Detalles Bibliográficos
Autores principales: Ou, Weijun, Yang, Joshua, Simanauskaite, Juste, Choi, Matthew, Castellanos, Demi M., Chang, Rudy, Sun, Jiahong, Jagadeesan, Nataraj, Parfitt, Karen D., Cribbs, David H., Sumbria, Rachita K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719395/
https://www.ncbi.nlm.nih.gov/pubmed/34972522
http://dx.doi.org/10.1186/s12974-021-02332-7

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