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The Vaginal Microbiome: V. Therapeutic Modalities of Vaginal Microbiome Engineering and Research Challenges

OBJECTIVE: This series of articles, titled The Vaginal Microbiome (VMB), written on behalf of the International Society for the Study of Vulvovaginal Disease, aims to summarize the recent findings and understanding of the vaginal bacterial microbiota, mainly regarding areas relevant to clinicians sp...

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Autores principales: Vieira-Baptista, Pedro, De Seta, Francesco, Verstraelen, Hans, Ventolini, Gary, Lonnee-Hoffmann, Risa, Lev-Sagie, Ahinoam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719494/
https://www.ncbi.nlm.nih.gov/pubmed/34928260
http://dx.doi.org/10.1097/LGT.0000000000000647
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author Vieira-Baptista, Pedro
De Seta, Francesco
Verstraelen, Hans
Ventolini, Gary
Lonnee-Hoffmann, Risa
Lev-Sagie, Ahinoam
author_facet Vieira-Baptista, Pedro
De Seta, Francesco
Verstraelen, Hans
Ventolini, Gary
Lonnee-Hoffmann, Risa
Lev-Sagie, Ahinoam
author_sort Vieira-Baptista, Pedro
collection PubMed
description OBJECTIVE: This series of articles, titled The Vaginal Microbiome (VMB), written on behalf of the International Society for the Study of Vulvovaginal Disease, aims to summarize the recent findings and understanding of the vaginal bacterial microbiota, mainly regarding areas relevant to clinicians specializing in vulvovaginal disorders. MATERIALS AND METHODS: A search of PubMed database was performed, using the search terms “vaginal microbiome” with “treatment,” “diagnosis,” and “research.” Full article texts were reviewed. Reference lists were screened for additional articles. RESULTS: The currently available approaches for treating vaginitis or attempting to modulate the VMB are often insufficient. It has traditionally relied on the use of antibiotics, antiseptics, and antifungals. The fifth and last article of this series discusses the new and/or alternative therapeutic modalities. It addresses the role of probiotics, prebiotics and symbiotics, activated charcoal, biofilm disrupting agents, acidifying agents, phage therapy, and the concept of vaginal microbiome transplant. The challenges facing the research of VMB, including the clinical impact of microbiome manipulation, classification, and new diagnostic approaches are discussed. CONCLUSIONS: Microbiome research has grown dramatically in recent years, motivated by innovations in technology and decrease in analysis costs. This research has yielded huge insight into the nature of microbial communities, their interactions, and effects with their hosts and other microbes. Further understanding of the bacterial, fungal, phage, and viral microbiomes in combination with host genetics, immunologic status, and environmental factors is needed to better understand and provide personalized medical diagnostics and interventions to improve women's health.
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spelling pubmed-87194942022-01-07 The Vaginal Microbiome: V. Therapeutic Modalities of Vaginal Microbiome Engineering and Research Challenges Vieira-Baptista, Pedro De Seta, Francesco Verstraelen, Hans Ventolini, Gary Lonnee-Hoffmann, Risa Lev-Sagie, Ahinoam J Low Genit Tract Dis Special Section—The Vaginal Microbiome OBJECTIVE: This series of articles, titled The Vaginal Microbiome (VMB), written on behalf of the International Society for the Study of Vulvovaginal Disease, aims to summarize the recent findings and understanding of the vaginal bacterial microbiota, mainly regarding areas relevant to clinicians specializing in vulvovaginal disorders. MATERIALS AND METHODS: A search of PubMed database was performed, using the search terms “vaginal microbiome” with “treatment,” “diagnosis,” and “research.” Full article texts were reviewed. Reference lists were screened for additional articles. RESULTS: The currently available approaches for treating vaginitis or attempting to modulate the VMB are often insufficient. It has traditionally relied on the use of antibiotics, antiseptics, and antifungals. The fifth and last article of this series discusses the new and/or alternative therapeutic modalities. It addresses the role of probiotics, prebiotics and symbiotics, activated charcoal, biofilm disrupting agents, acidifying agents, phage therapy, and the concept of vaginal microbiome transplant. The challenges facing the research of VMB, including the clinical impact of microbiome manipulation, classification, and new diagnostic approaches are discussed. CONCLUSIONS: Microbiome research has grown dramatically in recent years, motivated by innovations in technology and decrease in analysis costs. This research has yielded huge insight into the nature of microbial communities, their interactions, and effects with their hosts and other microbes. Further understanding of the bacterial, fungal, phage, and viral microbiomes in combination with host genetics, immunologic status, and environmental factors is needed to better understand and provide personalized medical diagnostics and interventions to improve women's health. Lippincott Williams & Wilkins 2021-12-20 /pmc/articles/PMC8719494/ /pubmed/34928260 http://dx.doi.org/10.1097/LGT.0000000000000647 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the ASCCP. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Special Section—The Vaginal Microbiome
Vieira-Baptista, Pedro
De Seta, Francesco
Verstraelen, Hans
Ventolini, Gary
Lonnee-Hoffmann, Risa
Lev-Sagie, Ahinoam
The Vaginal Microbiome: V. Therapeutic Modalities of Vaginal Microbiome Engineering and Research Challenges
title The Vaginal Microbiome: V. Therapeutic Modalities of Vaginal Microbiome Engineering and Research Challenges
title_full The Vaginal Microbiome: V. Therapeutic Modalities of Vaginal Microbiome Engineering and Research Challenges
title_fullStr The Vaginal Microbiome: V. Therapeutic Modalities of Vaginal Microbiome Engineering and Research Challenges
title_full_unstemmed The Vaginal Microbiome: V. Therapeutic Modalities of Vaginal Microbiome Engineering and Research Challenges
title_short The Vaginal Microbiome: V. Therapeutic Modalities of Vaginal Microbiome Engineering and Research Challenges
title_sort vaginal microbiome: v. therapeutic modalities of vaginal microbiome engineering and research challenges
topic Special Section—The Vaginal Microbiome
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719494/
https://www.ncbi.nlm.nih.gov/pubmed/34928260
http://dx.doi.org/10.1097/LGT.0000000000000647
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