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WASP integrates substrate topology and cell polarity to guide neutrophil migration

To control their movement, cells need to coordinate actin assembly with the geometric features of their substrate. Here, we uncover a role for the actin regulator WASP in the 3D migration of neutrophils. We show that WASP responds to substrate topology by enriching to sites of inward, substrate-indu...

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Detalles Bibliográficos
Autores principales:	Brunetti, Rachel M., Kockelkoren, Gabriele, Raghavan, Preethi, Bell, George R.R., Britain, Derek, Puri, Natasha, Collins, Sean R., Leonetti, Manuel D., Stamou, Dimitrios, Weiner, Orion D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719638/ https://www.ncbi.nlm.nih.gov/pubmed/34964841 http://dx.doi.org/10.1083/jcb.202104046

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