Cargando…

Identification of a distal RXFP1 gene enhancer with differential activity in fibrotic lung fibroblasts involving AP-1

Relaxin/insulin-like family peptide receptor 1 (RXFP1) mediates relaxin’s antifibrotic effects and has reduced expression in the lung and skin of patients with fibrotic interstitial lung disease (fILD) including idiopathic pulmonary fibrosis (IPF) and systemic sclerosis (SSc). This may explain the f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Ting-Yun, Li, Xiaoyun, Goobie, Gillian C., Hung, Ching-Hsia, Hung, Tin-Kan, Hamilton, Kyle, Bahudhanapati, Harinath, Tan, Jiangning, Kass, Daniel J., Zhang, Yingze
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719731/ https://www.ncbi.nlm.nih.gov/pubmed/34972106 http://dx.doi.org/10.1371/journal.pone.0254466

Ejemplares similares

The relaxin family peptide receptor 1 (RXFP1): An emerging player in human health and disease
por: Chen, Ting‐Yun, et al.
Publicado: (2020)

Integrating the Integrated Stress Response
por: Bahudhanapati, Harinath, et al.
Publicado: (2022)

In a Class of Their Own – RXFP1 and RXFP2 are Unique Members of the LGR Family
por: Petrie, Emma J., et al.
Publicado: (2015)

Toll-Interacting Protein in Pulmonary Diseases. Abiding by the Goldilocks Principle
por: Li, Xiaoyun, et al.
Publicado: (2021)

Relaxin Receptor RXFP1 and RXFP2 Expression in Ligament, Tendon, and Shoulder Joint Capsule of Rats
por: Kim, Jae Hyung, et al.
Publicado: (2016)

Relaxin family peptide receptors Rxfp1 and Rxfp2: mapping of the mRNA and protein distribution in the reproductive tract of the male rat
por: Filonzi, Marcelo, et al.
Publicado: (2007)

Changes in Knee Laxity and Relaxin Receptor Isoforms Expression (RXFP1/RXFP2) in the Knee throughout Estrous Cycle Phases in Rodents
por: Dehghan, Firouzeh, et al.
Publicado: (2016)

Evolution of Vertebrate Adam Genes; Duplication of Testicular Adams from Ancient Adam9/9-like Loci
por: Bahudhanapati, Harinath, et al.
Publicado: (2015)

Chimeric RXFP1 and RXFP2 Receptors Highlight the Similar Mechanism of Activation Utilizing Their N-Terminal Low-Density Lipoprotein Class A Modules
por: Bruell, Shoni, et al.
Publicado: (2013)

Sex-Steroid Regulation of Relaxin Receptor Isoforms (RXFP1 & RXFP2) Expression in the Patellar Tendon and Lateral Collateral Ligament of Female WKY Rats
por: Dehghan, Firouzeh, et al.
Publicado: (2014)

Septal GABA and Glutamate Neurons Express RXFP3 mRNA and Depletion of Septal RXFP3 Impaired Spatial Search Strategy and Long-Term Reference Memory in Adult Mice
por: Haidar, Mouna, et al.
Publicado: (2019)

Association of Particulate Matter Exposure With Lung Function and Mortality Among Patients With Fibrotic Interstitial Lung Disease
por: Goobie, Gillian C., et al.
Publicado: (2022)

Differential Level of RXFP3 Expression in Dopaminergic Neurons Within the Arcuate Nucleus, Dorsomedial Hypothalamus and Ventral Tegmental Area of RXFP3-Cre/tdTomato Mice
por: Voglsanger, Lara M., et al.
Publicado: (2021)

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1
por: Kocan, Martina, et al.
Publicado: (2017)

Genomic Classifiers in Diagnosing Interstitial Lung Disease: Finding the Right Place at the Right Time
por: Goobie, Gillian C., et al.
Publicado: (2022)

RHBDF1 promotes AP-1-activated endothelial–mesenchymal transition in tumor fibrotic stroma formation
por: Gao, Shan, et al.
Publicado: (2021)

Familial bilateral cryptorchidism is caused by recessive variants in RXFP2
por: Ayers, Katie, et al.
Publicado: (2019)

A 1.8‐kb insertion in the 3′‐UTR of RXFP2 is associated with polledness in sheep
por: Wiedemar, Natalie, et al.
Publicado: (2015)

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1
por: Sethi, Ashish, et al.
Publicado: (2016)

In search of a small molecule agonist of the relaxin receptor RXFP1 for the treatment of liver fibrosis
por: McBride, Andrew, et al.
Publicado: (2017)

Serelaxin alleviates cardiac fibrosis through inhibiting endothelial-to-mesenchymal transition via RXFP1
por: Wilhelmi, Tim, et al.
Publicado: (2020)

Rare surfactant‐related variants in familial and sporadic pulmonary fibrosis
por: Sutton, Rachel M., et al.
Publicado: (2022)

In Vitro Pharmacological Characterization of RXFP3 Allosterism: An Example of Probe Dependency
por: Alvarez-Jaimes, Lily, et al.
Publicado: (2012)

Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3
por: Bathgate, Ross A. D., et al.
Publicado: (2013)

RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer
por: Thanasupawat, Thatchawan, et al.
Publicado: (2015)

Transcriptional and Proteomic Characterization of Telomere-Induced Senescence in a Human Alveolar Epithelial Cell Line
por: Sullivan, Daniel I., et al.
Publicado: (2021)

Rac Inhibition Reverses the Phenotype of Fibrotic Fibroblasts
por: Shi-wen, Xu, et al.
Publicado: (2009)

Dissecting Fibroblast Heterogeneity in Health and Fibrotic Disease
por: Shaw, Tanya J, et al.
Publicado: (2020)

Relaxin 2/RXFP1 Signaling Induces Cell Invasion via the β-Catenin Pathway in Endometrial Cancer
por: Fue, Misaki, et al.
Publicado: (2018)

Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis
por: Hoare, Bradley L., et al.
Publicado: (2018)

The Fate of Spermatogonial Stem Cells in the Cryptorchid Testes of RXFP2 Deficient Mice
por: Ferguson, Lydia, et al.
Publicado: (2013)

Engineering of chimeric peptides as antagonists for the G protein-coupled receptor, RXFP4
por: Praveen, Praveen, et al.
Publicado: (2019)

The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease
por: Leysen, Hanne, et al.
Publicado: (2022)

Polymer-Functionalized Mitochondrial Transplantation to Fibroblasts Counteracts a Pro-Fibrotic Phenotype
por: Baudo, Gherardo, et al.
Publicado: (2023)

Histone Deacetylase Inhibition Downregulates Collagen 3A1 in Fibrotic Lung Fibroblasts
por: Zhang, Xiangyu, et al.
Publicado: (2013)

Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1
por: Jin, Jin, et al.
Publicado: (2019)

Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis
por: Leavitt, Tripp, et al.
Publicado: (2020)

Resveratrol inhibits TGF-β1–induced fibrotic effects in human pterygium fibroblasts
por: Fan, Jianwu, et al.
Publicado: (2023)

Mass spectrometry detection of inhaled drug in distal fibrotic lung
por: Mikolasch, Theresia A., et al.
Publicado: (2022)

Fibrotic response in fibroblasts from congenital disorders of glycosylation
por: Lecca, M Rita, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_hbmsdptsugud54p4ghdttoi7sj