Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia

Aggregation and cytoplasmic mislocalization of TDP-43 are pathological hallmarks of amyotrophic lateral sclerosis and frontotemporal dementia spectrum. However, the molecular mechanism by which TDP-43 aggregates form and cause neurodegeneration remains poorly understood. Cyclophilin A, also known as...

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Detalles Bibliográficos
Autores principales: Pasetto, Laura, Grassano, Maurizio, Pozzi, Silvia, Luotti, Silvia, Sammali, Eliana, Migazzi, Alice, Basso, Manuela, Spagnolli, Giovanni, Biasini, Emiliano, Micotti, Edoardo, Cerovic, Milica, Carli, Mirjana, Forloni, Gianluigi, De Marco, Giovanni, Manera, Umberto, Moglia, Cristina, Mora, Gabriele, Traynor, Bryan J, Chiò, Adriano, Calvo, Andrea, Bonetto, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719849/
https://www.ncbi.nlm.nih.gov/pubmed/34972208
http://dx.doi.org/10.1093/brain/awab333

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