Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ

Transmembrane signaling proteins couple extracytosolic sensors to cytosolic effectors. Here, we examine how binding of Mg(2+) to the sensor domain of an E. coli two component histidine kinase (HK), PhoQ, modulates its cytoplasmic kinase domain. We use cysteine-crosslinking and reporter-gene assays t...

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Detalles Bibliográficos
Autores principales: Mensa, Bruk, Polizzi, Nicholas F, Molnar, Kathleen S, Natale, Andrew M, Lemmin, Thomas, DeGrado, William F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719878/
https://www.ncbi.nlm.nih.gov/pubmed/34904568
http://dx.doi.org/10.7554/eLife.73336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719878/
https://www.ncbi.nlm.nih.gov/pubmed/34904568
http://dx.doi.org/10.7554/eLife.73336

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