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Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ

Transmembrane signaling proteins couple extracytosolic sensors to cytosolic effectors. Here, we examine how binding of Mg(2+) to the sensor domain of an E. coli two component histidine kinase (HK), PhoQ, modulates its cytoplasmic kinase domain. We use cysteine-crosslinking and reporter-gene assays t...

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Detalles Bibliográficos
Autores principales:	Mensa, Bruk, Polizzi, Nicholas F, Molnar, Kathleen S, Natale, Andrew M, Lemmin, Thomas, DeGrado, William F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719878/ https://www.ncbi.nlm.nih.gov/pubmed/34904568 http://dx.doi.org/10.7554/eLife.73336

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