PEGylation increases antitumoral activity of arginine deiminase of Streptococcus pyogenes

ABSTRACT: Arginine auxotrophy is a metabolic defect that renders tumor cells vulnerable towards arginine-depleting substances, such as arginine deiminase (ADI) from Streptococcus pyogenes (SpyADI). Previously, we confirmed SpyADI susceptibility on patient-derived glioblastoma multiforme (GBM) models...

Descripción completa

Detalles Bibliográficos
Autores principales: Schwarz, Rico, Zitzow, Eric, Fiebig, Adina, Hering, Silvio, Humboldt, Yvonne, Schoenwaelder, Nina, Kämpfer, Neele, Volkmar, Kerren, Hinz, Burkhard, Kreikemeyer, Bernd, Maletzki, Claudia, Fiedler, Tomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Biotechnologically Relevant Enzymes and Proteins
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720082/
https://www.ncbi.nlm.nih.gov/pubmed/34910240
http://dx.doi.org/10.1007/s00253-021-11728-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720082/
https://www.ncbi.nlm.nih.gov/pubmed/34910240
http://dx.doi.org/10.1007/s00253-021-11728-7

Ejemplares similares