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PEGylation increases antitumoral activity of arginine deiminase of Streptococcus pyogenes

ABSTRACT: Arginine auxotrophy is a metabolic defect that renders tumor cells vulnerable towards arginine-depleting substances, such as arginine deiminase (ADI) from Streptococcus pyogenes (SpyADI). Previously, we confirmed SpyADI susceptibility on patient-derived glioblastoma multiforme (GBM) models...

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Detalles Bibliográficos
Autores principales:	Schwarz, Rico, Zitzow, Eric, Fiebig, Adina, Hering, Silvio, Humboldt, Yvonne, Schoenwaelder, Nina, Kämpfer, Neele, Volkmar, Kerren, Hinz, Burkhard, Kreikemeyer, Bernd, Maletzki, Claudia, Fiedler, Tomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Biotechnologically Relevant Enzymes and Proteins
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720082/ https://www.ncbi.nlm.nih.gov/pubmed/34910240 http://dx.doi.org/10.1007/s00253-021-11728-7

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