Prevalence of Pathogenic and Potentially Pathogenic Inborn Error of Immunity Associated Variants in Children with Severe Sepsis

PURPOSE: Our understanding of inborn errors of immunity is increasing; however, their contribution to pediatric sepsis is unknown. METHODS: We used whole-exome sequencing (WES) to characterize variants in genes related to monogenic immunologic disorders in 330 children admitted to intensive care for...

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Detalles Bibliográficos
Autores principales: Kernan, Kate F., Ghaloul-Gonzalez, Lina, Vockley, Jerry, Lamb, Janette, Hollingshead, Deborah, Chandran, Uma, Sethi, Rahil, Park, Hyun-Jung, Berg, Robert A., Wessel, David, Pollack, Murray M., Meert, Kathleen L., Hall, Mark W., Newth, Christopher J. L., Lin, John C., Doctor, Allan, Shanley, Tom, Cornell, Tim, Harrison, Rick E., Zuppa, Athena F., Banks, Russel, Reeder, Ron W., Holubkov, Richard, Notterman, Daniel A., Dean, J. Michael, Carcillo, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720168/
https://www.ncbi.nlm.nih.gov/pubmed/34973142
http://dx.doi.org/10.1007/s10875-021-01183-4

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