A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors

Receptor clustering is the first and critical step to activate apoptosis by death receptor-5 (DR5). The recent discovery of the autoinhibitory DR5 ectodomain has challenged the long-standing view of its mechanistic activation by the natural ligand Apo2L. Because the autoinhibitory residues have rema...

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Detalles Bibliográficos
Autores principales: Shivange, Gururaj, Mondal, Tanmoy, Lyerly, Evan, Bhatnagar, Sanchita, Landen, Charles N., Reddy, Shivani, Kim, Jonathan, Doan, Britney, Riddle, Paula, Tushir-Singh, Jogender
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720280/
https://www.ncbi.nlm.nih.gov/pubmed/34731630
http://dx.doi.org/10.1016/j.celrep.2021.109953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720280/
https://www.ncbi.nlm.nih.gov/pubmed/34731630
http://dx.doi.org/10.1016/j.celrep.2021.109953

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