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A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors
Receptor clustering is the first and critical step to activate apoptosis by death receptor-5 (DR5). The recent discovery of the autoinhibitory DR5 ectodomain has challenged the long-standing view of its mechanistic activation by the natural ligand Apo2L. Because the autoinhibitory residues have rema...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720280/ https://www.ncbi.nlm.nih.gov/pubmed/34731630 http://dx.doi.org/10.1016/j.celrep.2021.109953 |