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Celiac Disease, Beyond the Bowel: A Review of Its Neurological Manifestations

Celiac disease (CD) is a multi-systemic autoimmune condition that causes a hyperinflammatory response when gluten is ingested. There has been a shift in the clinical presentation of CD from a mere malabsorption disorder to an autoimmune condition that affects multiple organ systems, which could incr...

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Autores principales: Patel, Saawan C, Shreya, Devarashetty, Zamora, Diana I, Patel, Gautami S, Grossmann, Idan, Rodriguez, Kevin, Soni, Mridul, Joshi, Pranay K, Sange, Ibrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720288/
https://www.ncbi.nlm.nih.gov/pubmed/34984152
http://dx.doi.org/10.7759/cureus.20112
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author Patel, Saawan C
Shreya, Devarashetty
Zamora, Diana I
Patel, Gautami S
Grossmann, Idan
Rodriguez, Kevin
Soni, Mridul
Joshi, Pranay K
Sange, Ibrahim
author_facet Patel, Saawan C
Shreya, Devarashetty
Zamora, Diana I
Patel, Gautami S
Grossmann, Idan
Rodriguez, Kevin
Soni, Mridul
Joshi, Pranay K
Sange, Ibrahim
author_sort Patel, Saawan C
collection PubMed
description Celiac disease (CD) is a multi-systemic autoimmune condition that causes a hyperinflammatory response when gluten is ingested. There has been a shift in the clinical presentation of CD from a mere malabsorption disorder to an autoimmune condition that affects multiple organ systems, which could increase the rate of hospitalizations and a decreased quality of life. This article has compiled various studies that have explored the neurological manifestations of celiac disease, their epidemiology, possible pathogenic mechanisms, diagnosis, and treatment. The most common neurological conditions include gluten ataxia (GA), gluten neuropathy, gluten encephalopathy, and epilepsy which usually present as sporadic diseases which are difficult to diagnose in the absence of gastrointestinal (GI) symptoms. The treatment for most of these conditions is a gluten-free diet (GFD) regardless of GI involvement.
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spelling pubmed-87202882022-01-03 Celiac Disease, Beyond the Bowel: A Review of Its Neurological Manifestations Patel, Saawan C Shreya, Devarashetty Zamora, Diana I Patel, Gautami S Grossmann, Idan Rodriguez, Kevin Soni, Mridul Joshi, Pranay K Sange, Ibrahim Cureus Internal Medicine Celiac disease (CD) is a multi-systemic autoimmune condition that causes a hyperinflammatory response when gluten is ingested. There has been a shift in the clinical presentation of CD from a mere malabsorption disorder to an autoimmune condition that affects multiple organ systems, which could increase the rate of hospitalizations and a decreased quality of life. This article has compiled various studies that have explored the neurological manifestations of celiac disease, their epidemiology, possible pathogenic mechanisms, diagnosis, and treatment. The most common neurological conditions include gluten ataxia (GA), gluten neuropathy, gluten encephalopathy, and epilepsy which usually present as sporadic diseases which are difficult to diagnose in the absence of gastrointestinal (GI) symptoms. The treatment for most of these conditions is a gluten-free diet (GFD) regardless of GI involvement. Cureus 2021-12-02 /pmc/articles/PMC8720288/ /pubmed/34984152 http://dx.doi.org/10.7759/cureus.20112 Text en Copyright © 2021, Patel et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Patel, Saawan C
Shreya, Devarashetty
Zamora, Diana I
Patel, Gautami S
Grossmann, Idan
Rodriguez, Kevin
Soni, Mridul
Joshi, Pranay K
Sange, Ibrahim
Celiac Disease, Beyond the Bowel: A Review of Its Neurological Manifestations
title Celiac Disease, Beyond the Bowel: A Review of Its Neurological Manifestations
title_full Celiac Disease, Beyond the Bowel: A Review of Its Neurological Manifestations
title_fullStr Celiac Disease, Beyond the Bowel: A Review of Its Neurological Manifestations
title_full_unstemmed Celiac Disease, Beyond the Bowel: A Review of Its Neurological Manifestations
title_short Celiac Disease, Beyond the Bowel: A Review of Its Neurological Manifestations
title_sort celiac disease, beyond the bowel: a review of its neurological manifestations
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720288/
https://www.ncbi.nlm.nih.gov/pubmed/34984152
http://dx.doi.org/10.7759/cureus.20112
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