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Celiac Disease, Beyond the Bowel: A Review of Its Neurological Manifestations
Celiac disease (CD) is a multi-systemic autoimmune condition that causes a hyperinflammatory response when gluten is ingested. There has been a shift in the clinical presentation of CD from a mere malabsorption disorder to an autoimmune condition that affects multiple organ systems, which could incr...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720288/ https://www.ncbi.nlm.nih.gov/pubmed/34984152 http://dx.doi.org/10.7759/cureus.20112 |
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author | Patel, Saawan C Shreya, Devarashetty Zamora, Diana I Patel, Gautami S Grossmann, Idan Rodriguez, Kevin Soni, Mridul Joshi, Pranay K Sange, Ibrahim |
author_facet | Patel, Saawan C Shreya, Devarashetty Zamora, Diana I Patel, Gautami S Grossmann, Idan Rodriguez, Kevin Soni, Mridul Joshi, Pranay K Sange, Ibrahim |
author_sort | Patel, Saawan C |
collection | PubMed |
description | Celiac disease (CD) is a multi-systemic autoimmune condition that causes a hyperinflammatory response when gluten is ingested. There has been a shift in the clinical presentation of CD from a mere malabsorption disorder to an autoimmune condition that affects multiple organ systems, which could increase the rate of hospitalizations and a decreased quality of life. This article has compiled various studies that have explored the neurological manifestations of celiac disease, their epidemiology, possible pathogenic mechanisms, diagnosis, and treatment. The most common neurological conditions include gluten ataxia (GA), gluten neuropathy, gluten encephalopathy, and epilepsy which usually present as sporadic diseases which are difficult to diagnose in the absence of gastrointestinal (GI) symptoms. The treatment for most of these conditions is a gluten-free diet (GFD) regardless of GI involvement. |
format | Online Article Text |
id | pubmed-8720288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-87202882022-01-03 Celiac Disease, Beyond the Bowel: A Review of Its Neurological Manifestations Patel, Saawan C Shreya, Devarashetty Zamora, Diana I Patel, Gautami S Grossmann, Idan Rodriguez, Kevin Soni, Mridul Joshi, Pranay K Sange, Ibrahim Cureus Internal Medicine Celiac disease (CD) is a multi-systemic autoimmune condition that causes a hyperinflammatory response when gluten is ingested. There has been a shift in the clinical presentation of CD from a mere malabsorption disorder to an autoimmune condition that affects multiple organ systems, which could increase the rate of hospitalizations and a decreased quality of life. This article has compiled various studies that have explored the neurological manifestations of celiac disease, their epidemiology, possible pathogenic mechanisms, diagnosis, and treatment. The most common neurological conditions include gluten ataxia (GA), gluten neuropathy, gluten encephalopathy, and epilepsy which usually present as sporadic diseases which are difficult to diagnose in the absence of gastrointestinal (GI) symptoms. The treatment for most of these conditions is a gluten-free diet (GFD) regardless of GI involvement. Cureus 2021-12-02 /pmc/articles/PMC8720288/ /pubmed/34984152 http://dx.doi.org/10.7759/cureus.20112 Text en Copyright © 2021, Patel et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Patel, Saawan C Shreya, Devarashetty Zamora, Diana I Patel, Gautami S Grossmann, Idan Rodriguez, Kevin Soni, Mridul Joshi, Pranay K Sange, Ibrahim Celiac Disease, Beyond the Bowel: A Review of Its Neurological Manifestations |
title | Celiac Disease, Beyond the Bowel: A Review of Its Neurological Manifestations |
title_full | Celiac Disease, Beyond the Bowel: A Review of Its Neurological Manifestations |
title_fullStr | Celiac Disease, Beyond the Bowel: A Review of Its Neurological Manifestations |
title_full_unstemmed | Celiac Disease, Beyond the Bowel: A Review of Its Neurological Manifestations |
title_short | Celiac Disease, Beyond the Bowel: A Review of Its Neurological Manifestations |
title_sort | celiac disease, beyond the bowel: a review of its neurological manifestations |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720288/ https://www.ncbi.nlm.nih.gov/pubmed/34984152 http://dx.doi.org/10.7759/cureus.20112 |
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