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Efficacy of Colchicine and Budesonide in Improvement Outcomes of Patients with Coronavirus Infection 2019 in Damascus, Syria: A Randomized Control Trial

COVID-19 was reported in China in 2019 and has spread worldwide. Transmission occurs through respiratory secretions and, less commonly, through contaminated surfaces. The severity of the disease can range from asymptomatic to acute respiratory distress syndrome (ARDS). In this study, we aim to inves...

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Autores principales: Alsultan, Mohammad, Obeid, Ameer, Alsamarrai, Omar, Anan, Mohamed Taher, Bakr, Aliaa, Soliman, Nawwar, Kurdy, Mamdoh, Mosa, Muhannad Hag, Saleh, Zain, Hujij, Fatima, Barhoum, Jafar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720363/
https://www.ncbi.nlm.nih.gov/pubmed/34984065
http://dx.doi.org/10.1155/2021/2129006
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author Alsultan, Mohammad
Obeid, Ameer
Alsamarrai, Omar
Anan, Mohamed Taher
Bakr, Aliaa
Soliman, Nawwar
Kurdy, Mamdoh
Mosa, Muhannad Hag
Saleh, Zain
Hujij, Fatima
Barhoum, Jafar
author_facet Alsultan, Mohammad
Obeid, Ameer
Alsamarrai, Omar
Anan, Mohamed Taher
Bakr, Aliaa
Soliman, Nawwar
Kurdy, Mamdoh
Mosa, Muhannad Hag
Saleh, Zain
Hujij, Fatima
Barhoum, Jafar
author_sort Alsultan, Mohammad
collection PubMed
description COVID-19 was reported in China in 2019 and has spread worldwide. Transmission occurs through respiratory secretions and, less commonly, through contaminated surfaces. The severity of the disease can range from asymptomatic to acute respiratory distress syndrome (ARDS). In this study, we aim to investigate the efficacy of two agents (oral colchicine and budesonide inhaler) in COVID-19 infection management, compared with supportive care alone. 77 patients were admitted to the isolation section of Al Assad University Hospital, between the 1(st) of August and the 30(th) of August. A total of 49 patients were included in this randomized control trial, after excluding ineligible patients. The random sample was divided into three groups; the first group was supportive care plus colchicine, the second group was supportive care plus budesonide inhaler, and the control group was supportive care alone. PaO2/FiO2 was improved in the budesonide group, higher than the supportive and colchicine groups. The median hospitalization days were shorter when using colchicine or budesonide, opposed to supportive care alone (8 vs 10 days, respectively). 34 patients (69.3%) were discharged, and 27 patients (55.1%) were followed up until they were weaned from oxygen and made a complete recovery. There was a significant decrease in mortality with colchicine (3 patients; 21.4%) compared with supportive care (7 patients; 33.3%) and the budesonide group (5 patients; 35.7%).
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spelling pubmed-87203632022-01-03 Efficacy of Colchicine and Budesonide in Improvement Outcomes of Patients with Coronavirus Infection 2019 in Damascus, Syria: A Randomized Control Trial Alsultan, Mohammad Obeid, Ameer Alsamarrai, Omar Anan, Mohamed Taher Bakr, Aliaa Soliman, Nawwar Kurdy, Mamdoh Mosa, Muhannad Hag Saleh, Zain Hujij, Fatima Barhoum, Jafar Interdiscip Perspect Infect Dis Research Article COVID-19 was reported in China in 2019 and has spread worldwide. Transmission occurs through respiratory secretions and, less commonly, through contaminated surfaces. The severity of the disease can range from asymptomatic to acute respiratory distress syndrome (ARDS). In this study, we aim to investigate the efficacy of two agents (oral colchicine and budesonide inhaler) in COVID-19 infection management, compared with supportive care alone. 77 patients were admitted to the isolation section of Al Assad University Hospital, between the 1(st) of August and the 30(th) of August. A total of 49 patients were included in this randomized control trial, after excluding ineligible patients. The random sample was divided into three groups; the first group was supportive care plus colchicine, the second group was supportive care plus budesonide inhaler, and the control group was supportive care alone. PaO2/FiO2 was improved in the budesonide group, higher than the supportive and colchicine groups. The median hospitalization days were shorter when using colchicine or budesonide, opposed to supportive care alone (8 vs 10 days, respectively). 34 patients (69.3%) were discharged, and 27 patients (55.1%) were followed up until they were weaned from oxygen and made a complete recovery. There was a significant decrease in mortality with colchicine (3 patients; 21.4%) compared with supportive care (7 patients; 33.3%) and the budesonide group (5 patients; 35.7%). Hindawi 2021-12-31 /pmc/articles/PMC8720363/ /pubmed/34984065 http://dx.doi.org/10.1155/2021/2129006 Text en Copyright © 2021 Mohammad Alsultan et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Alsultan, Mohammad
Obeid, Ameer
Alsamarrai, Omar
Anan, Mohamed Taher
Bakr, Aliaa
Soliman, Nawwar
Kurdy, Mamdoh
Mosa, Muhannad Hag
Saleh, Zain
Hujij, Fatima
Barhoum, Jafar
Efficacy of Colchicine and Budesonide in Improvement Outcomes of Patients with Coronavirus Infection 2019 in Damascus, Syria: A Randomized Control Trial
title Efficacy of Colchicine and Budesonide in Improvement Outcomes of Patients with Coronavirus Infection 2019 in Damascus, Syria: A Randomized Control Trial
title_full Efficacy of Colchicine and Budesonide in Improvement Outcomes of Patients with Coronavirus Infection 2019 in Damascus, Syria: A Randomized Control Trial
title_fullStr Efficacy of Colchicine and Budesonide in Improvement Outcomes of Patients with Coronavirus Infection 2019 in Damascus, Syria: A Randomized Control Trial
title_full_unstemmed Efficacy of Colchicine and Budesonide in Improvement Outcomes of Patients with Coronavirus Infection 2019 in Damascus, Syria: A Randomized Control Trial
title_short Efficacy of Colchicine and Budesonide in Improvement Outcomes of Patients with Coronavirus Infection 2019 in Damascus, Syria: A Randomized Control Trial
title_sort efficacy of colchicine and budesonide in improvement outcomes of patients with coronavirus infection 2019 in damascus, syria: a randomized control trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720363/
https://www.ncbi.nlm.nih.gov/pubmed/34984065
http://dx.doi.org/10.1155/2021/2129006
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