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Primary spinal dorsal extramedullary germ cell tumor: A rare case report and literature review

BACKGROUND: Primary spinal extramedullary germ cell tumor are very rare. Germ cell tumor are similar histologically to germ cells of genital organs and may arise rarely from central and peripheral nervous system. CASE DESCRIPTION: We report a case of 20-year-old male who presented with progressive l...

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Autores principales: Vij, Mukesh, Bhardwaj, Sandeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Scientific Scholar 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720437/
https://www.ncbi.nlm.nih.gov/pubmed/34992920
http://dx.doi.org/10.25259/SNI_575_2021
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author Vij, Mukesh
Bhardwaj, Sandeep
author_facet Vij, Mukesh
Bhardwaj, Sandeep
author_sort Vij, Mukesh
collection PubMed
description BACKGROUND: Primary spinal extramedullary germ cell tumor are very rare. Germ cell tumor are similar histologically to germ cells of genital organs and may arise rarely from central and peripheral nervous system. CASE DESCRIPTION: We report a case of 20-year-old male who presented with progressive lower extremity weakness, spasticity, and numbness of legs. Patient was evaluated with magnetic resonance imaging dorsal spine which revealed extramedullary mass in dorsal (D2-D3) level with severe cord compression. Tumor was found to be extramedullary with histopathology consistent with germ cell tumor. Patient was given radiotherapy and chemotherapy postoperatively. CONCLUSION: Primary spinal extramedullary germ cell tumors are very rare and are very sensitive to radiation and chemotherapy. Various management and treatment protocols are available across institutions in the world. We recommend adequate decompression of cord with biopsy followed by local radiation and chemotherapy. As these are rare tumors, presenting with significant neurological deficits should always be kept in the differential diagnosis.
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spelling pubmed-87204372022-01-05 Primary spinal dorsal extramedullary germ cell tumor: A rare case report and literature review Vij, Mukesh Bhardwaj, Sandeep Surg Neurol Int Case Report BACKGROUND: Primary spinal extramedullary germ cell tumor are very rare. Germ cell tumor are similar histologically to germ cells of genital organs and may arise rarely from central and peripheral nervous system. CASE DESCRIPTION: We report a case of 20-year-old male who presented with progressive lower extremity weakness, spasticity, and numbness of legs. Patient was evaluated with magnetic resonance imaging dorsal spine which revealed extramedullary mass in dorsal (D2-D3) level with severe cord compression. Tumor was found to be extramedullary with histopathology consistent with germ cell tumor. Patient was given radiotherapy and chemotherapy postoperatively. CONCLUSION: Primary spinal extramedullary germ cell tumors are very rare and are very sensitive to radiation and chemotherapy. Various management and treatment protocols are available across institutions in the world. We recommend adequate decompression of cord with biopsy followed by local radiation and chemotherapy. As these are rare tumors, presenting with significant neurological deficits should always be kept in the differential diagnosis. Scientific Scholar 2021-12-08 /pmc/articles/PMC8720437/ /pubmed/34992920 http://dx.doi.org/10.25259/SNI_575_2021 Text en Copyright: © 2021 Surgical Neurology International https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Vij, Mukesh
Bhardwaj, Sandeep
Primary spinal dorsal extramedullary germ cell tumor: A rare case report and literature review
title Primary spinal dorsal extramedullary germ cell tumor: A rare case report and literature review
title_full Primary spinal dorsal extramedullary germ cell tumor: A rare case report and literature review
title_fullStr Primary spinal dorsal extramedullary germ cell tumor: A rare case report and literature review
title_full_unstemmed Primary spinal dorsal extramedullary germ cell tumor: A rare case report and literature review
title_short Primary spinal dorsal extramedullary germ cell tumor: A rare case report and literature review
title_sort primary spinal dorsal extramedullary germ cell tumor: a rare case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720437/
https://www.ncbi.nlm.nih.gov/pubmed/34992920
http://dx.doi.org/10.25259/SNI_575_2021
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