Cargando…
Tiger-Striped PASH: Recognition of a Unique Morphology Allows for a Zippered-Up Diagnosis of Pseudoangiomatous Stromal Hyperplasia of Breast
Pseudoangiomatous stromal hyperplasia (PASH) of the breast is histologically characterized by anastomosing and slit-like spaces invested by collagenous stroma and lined by flattened, spindle cells. These clear spaces that may mimic microscopic vascular channels do not contain red blood cells. Immuno...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720602/ https://www.ncbi.nlm.nih.gov/pubmed/34987877 http://dx.doi.org/10.1155/2021/7697987 |
_version_ | 1784625157707399168 |
---|---|
author | Sakibuzzaman, Mohamad Kendziora, Ryan W. Ghosh, Toshi Solanki, Malvika H. Conners, Amy Lynn Ahlberg, Lisa J. Sturgis, Charles D. |
author_facet | Sakibuzzaman, Mohamad Kendziora, Ryan W. Ghosh, Toshi Solanki, Malvika H. Conners, Amy Lynn Ahlberg, Lisa J. Sturgis, Charles D. |
author_sort | Sakibuzzaman, Mohamad |
collection | PubMed |
description | Pseudoangiomatous stromal hyperplasia (PASH) of the breast is histologically characterized by anastomosing and slit-like spaces invested by collagenous stroma and lined by flattened, spindle cells. These clear spaces that may mimic microscopic vascular channels do not contain red blood cells. Immunohistochemistry (IHC) studies may also help to confirm a diagnosis of PASH, with the spindled cells marking positively with CD34 and PR while demonstrating no reactivity with more specific endothelial antigens such as CD31 and ERG. In the current case, a 39-year-old female was diagnosed with cellular PASH of the right breast with unique histological patterns showing “tiger-striped” and “zippered” histologies. To our knowledge, this is the first report of these unique variant PASH morphologies. |
format | Online Article Text |
id | pubmed-8720602 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-87206022022-01-04 Tiger-Striped PASH: Recognition of a Unique Morphology Allows for a Zippered-Up Diagnosis of Pseudoangiomatous Stromal Hyperplasia of Breast Sakibuzzaman, Mohamad Kendziora, Ryan W. Ghosh, Toshi Solanki, Malvika H. Conners, Amy Lynn Ahlberg, Lisa J. Sturgis, Charles D. Case Rep Pathol Case Report Pseudoangiomatous stromal hyperplasia (PASH) of the breast is histologically characterized by anastomosing and slit-like spaces invested by collagenous stroma and lined by flattened, spindle cells. These clear spaces that may mimic microscopic vascular channels do not contain red blood cells. Immunohistochemistry (IHC) studies may also help to confirm a diagnosis of PASH, with the spindled cells marking positively with CD34 and PR while demonstrating no reactivity with more specific endothelial antigens such as CD31 and ERG. In the current case, a 39-year-old female was diagnosed with cellular PASH of the right breast with unique histological patterns showing “tiger-striped” and “zippered” histologies. To our knowledge, this is the first report of these unique variant PASH morphologies. Hindawi 2021-12-26 /pmc/articles/PMC8720602/ /pubmed/34987877 http://dx.doi.org/10.1155/2021/7697987 Text en Copyright © 2021 Mohamad Sakibuzzaman et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Sakibuzzaman, Mohamad Kendziora, Ryan W. Ghosh, Toshi Solanki, Malvika H. Conners, Amy Lynn Ahlberg, Lisa J. Sturgis, Charles D. Tiger-Striped PASH: Recognition of a Unique Morphology Allows for a Zippered-Up Diagnosis of Pseudoangiomatous Stromal Hyperplasia of Breast |
title | Tiger-Striped PASH: Recognition of a Unique Morphology Allows for a Zippered-Up Diagnosis of Pseudoangiomatous Stromal Hyperplasia of Breast |
title_full | Tiger-Striped PASH: Recognition of a Unique Morphology Allows for a Zippered-Up Diagnosis of Pseudoangiomatous Stromal Hyperplasia of Breast |
title_fullStr | Tiger-Striped PASH: Recognition of a Unique Morphology Allows for a Zippered-Up Diagnosis of Pseudoangiomatous Stromal Hyperplasia of Breast |
title_full_unstemmed | Tiger-Striped PASH: Recognition of a Unique Morphology Allows for a Zippered-Up Diagnosis of Pseudoangiomatous Stromal Hyperplasia of Breast |
title_short | Tiger-Striped PASH: Recognition of a Unique Morphology Allows for a Zippered-Up Diagnosis of Pseudoangiomatous Stromal Hyperplasia of Breast |
title_sort | tiger-striped pash: recognition of a unique morphology allows for a zippered-up diagnosis of pseudoangiomatous stromal hyperplasia of breast |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720602/ https://www.ncbi.nlm.nih.gov/pubmed/34987877 http://dx.doi.org/10.1155/2021/7697987 |
work_keys_str_mv | AT sakibuzzamanmohamad tigerstripedpashrecognitionofauniquemorphologyallowsforazipperedupdiagnosisofpseudoangiomatousstromalhyperplasiaofbreast AT kendzioraryanw tigerstripedpashrecognitionofauniquemorphologyallowsforazipperedupdiagnosisofpseudoangiomatousstromalhyperplasiaofbreast AT ghoshtoshi tigerstripedpashrecognitionofauniquemorphologyallowsforazipperedupdiagnosisofpseudoangiomatousstromalhyperplasiaofbreast AT solankimalvikah tigerstripedpashrecognitionofauniquemorphologyallowsforazipperedupdiagnosisofpseudoangiomatousstromalhyperplasiaofbreast AT connersamylynn tigerstripedpashrecognitionofauniquemorphologyallowsforazipperedupdiagnosisofpseudoangiomatousstromalhyperplasiaofbreast AT ahlberglisaj tigerstripedpashrecognitionofauniquemorphologyallowsforazipperedupdiagnosisofpseudoangiomatousstromalhyperplasiaofbreast AT sturgischarlesd tigerstripedpashrecognitionofauniquemorphologyallowsforazipperedupdiagnosisofpseudoangiomatousstromalhyperplasiaofbreast |