Cargando…

Effect of Specific Acupuncture Therapy Combined with Rehabilitation Training on Incomplete Spinal Cord Injury: A Randomized Clinical Trial

Acupuncture therapies were used to treat spinal cord injury (SCI) and its complications. To assess the effect of a specific acupuncture therapy combined with rehabilitation training for inpatients with incomplete SCI, we conducted an assessor-blinded, randomized controlled clinical trial in the Depa...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiong, Feng, Lu, Jingkang, Pan, Hongxia, Wang, Fengyi, Huang, Yaqin, Liu, Yiwei, Li, Lingxin, Zhang, Rengang, Wang, Yulong, He, Chengqi, Quan, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720606/
https://www.ncbi.nlm.nih.gov/pubmed/34987595
http://dx.doi.org/10.1155/2021/5671998
_version_ 1784625158674186240
author Xiong, Feng
Lu, Jingkang
Pan, Hongxia
Wang, Fengyi
Huang, Yaqin
Liu, Yiwei
Li, Lingxin
Zhang, Rengang
Wang, Yulong
He, Chengqi
Quan, Wei
author_facet Xiong, Feng
Lu, Jingkang
Pan, Hongxia
Wang, Fengyi
Huang, Yaqin
Liu, Yiwei
Li, Lingxin
Zhang, Rengang
Wang, Yulong
He, Chengqi
Quan, Wei
author_sort Xiong, Feng
collection PubMed
description Acupuncture therapies were used to treat spinal cord injury (SCI) and its complications. To assess the effect of a specific acupuncture therapy combined with rehabilitation training for inpatients with incomplete SCI, we conducted an assessor-blinded, randomized controlled clinical trial in the Department of Rehabilitation Medicine Center in West China Hospital, Sichuan University. Seventy-two participants diagnosed with incomplete SCI were randomly assigned into 3 groups of 24 patients each, with data collection completed in December, 2019. Participants were randomly assigned (1 : 1 : 1) to 3 groups to receive treatment for 4 weeks, 5 times/week of acupuncture for Continuous Acupuncture Treatment (CAT) group, 3 times/week for Intermittent Acupuncture Treatment (IAT) group, and no acupuncture for Control group; all 3 groups received routine rehabilitation training. The primary outcome was the change of American Spinal Injury Association (ASIA) motor score from baseline to week 4. Secondary outcomes included sensory score, Modified Barthel Index (MBI). At week 4, CAT group had a higher motor score and MBI score increase than the control group (mean difference 10.52, 17.36; p < 0.001, p < 0.01, respectively). CAT group had more increase in motor score and MBI than IAT group (mean difference 5.55, 14.77; p < 0.05, p < 0.05, respectively). But the difference among groups in the increase of sensory score was not statistically significant. Acupuncture resulted in a higher motor score and MBI after 4 weeks. And the dosage of 5/week led to more improvement in motor score and MBI than that of 3/week. The results suggested that a dosage of 5/week of acupuncture is safe and more effective for SCI than 3/week. But further research is needed to determine the best intervention dosage, long-term efficacy, and underlying mechanism. This trial is registered with ChiCTR1900021530.
format Online
Article
Text
id pubmed-8720606
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-87206062022-01-04 Effect of Specific Acupuncture Therapy Combined with Rehabilitation Training on Incomplete Spinal Cord Injury: A Randomized Clinical Trial Xiong, Feng Lu, Jingkang Pan, Hongxia Wang, Fengyi Huang, Yaqin Liu, Yiwei Li, Lingxin Zhang, Rengang Wang, Yulong He, Chengqi Quan, Wei Evid Based Complement Alternat Med Research Article Acupuncture therapies were used to treat spinal cord injury (SCI) and its complications. To assess the effect of a specific acupuncture therapy combined with rehabilitation training for inpatients with incomplete SCI, we conducted an assessor-blinded, randomized controlled clinical trial in the Department of Rehabilitation Medicine Center in West China Hospital, Sichuan University. Seventy-two participants diagnosed with incomplete SCI were randomly assigned into 3 groups of 24 patients each, with data collection completed in December, 2019. Participants were randomly assigned (1 : 1 : 1) to 3 groups to receive treatment for 4 weeks, 5 times/week of acupuncture for Continuous Acupuncture Treatment (CAT) group, 3 times/week for Intermittent Acupuncture Treatment (IAT) group, and no acupuncture for Control group; all 3 groups received routine rehabilitation training. The primary outcome was the change of American Spinal Injury Association (ASIA) motor score from baseline to week 4. Secondary outcomes included sensory score, Modified Barthel Index (MBI). At week 4, CAT group had a higher motor score and MBI score increase than the control group (mean difference 10.52, 17.36; p < 0.001, p < 0.01, respectively). CAT group had more increase in motor score and MBI than IAT group (mean difference 5.55, 14.77; p < 0.05, p < 0.05, respectively). But the difference among groups in the increase of sensory score was not statistically significant. Acupuncture resulted in a higher motor score and MBI after 4 weeks. And the dosage of 5/week led to more improvement in motor score and MBI than that of 3/week. The results suggested that a dosage of 5/week of acupuncture is safe and more effective for SCI than 3/week. But further research is needed to determine the best intervention dosage, long-term efficacy, and underlying mechanism. This trial is registered with ChiCTR1900021530. Hindawi 2021-12-26 /pmc/articles/PMC8720606/ /pubmed/34987595 http://dx.doi.org/10.1155/2021/5671998 Text en Copyright © 2021 Feng Xiong et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Xiong, Feng
Lu, Jingkang
Pan, Hongxia
Wang, Fengyi
Huang, Yaqin
Liu, Yiwei
Li, Lingxin
Zhang, Rengang
Wang, Yulong
He, Chengqi
Quan, Wei
Effect of Specific Acupuncture Therapy Combined with Rehabilitation Training on Incomplete Spinal Cord Injury: A Randomized Clinical Trial
title Effect of Specific Acupuncture Therapy Combined with Rehabilitation Training on Incomplete Spinal Cord Injury: A Randomized Clinical Trial
title_full Effect of Specific Acupuncture Therapy Combined with Rehabilitation Training on Incomplete Spinal Cord Injury: A Randomized Clinical Trial
title_fullStr Effect of Specific Acupuncture Therapy Combined with Rehabilitation Training on Incomplete Spinal Cord Injury: A Randomized Clinical Trial
title_full_unstemmed Effect of Specific Acupuncture Therapy Combined with Rehabilitation Training on Incomplete Spinal Cord Injury: A Randomized Clinical Trial
title_short Effect of Specific Acupuncture Therapy Combined with Rehabilitation Training on Incomplete Spinal Cord Injury: A Randomized Clinical Trial
title_sort effect of specific acupuncture therapy combined with rehabilitation training on incomplete spinal cord injury: a randomized clinical trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720606/
https://www.ncbi.nlm.nih.gov/pubmed/34987595
http://dx.doi.org/10.1155/2021/5671998
work_keys_str_mv AT xiongfeng effectofspecificacupuncturetherapycombinedwithrehabilitationtrainingonincompletespinalcordinjuryarandomizedclinicaltrial
AT lujingkang effectofspecificacupuncturetherapycombinedwithrehabilitationtrainingonincompletespinalcordinjuryarandomizedclinicaltrial
AT panhongxia effectofspecificacupuncturetherapycombinedwithrehabilitationtrainingonincompletespinalcordinjuryarandomizedclinicaltrial
AT wangfengyi effectofspecificacupuncturetherapycombinedwithrehabilitationtrainingonincompletespinalcordinjuryarandomizedclinicaltrial
AT huangyaqin effectofspecificacupuncturetherapycombinedwithrehabilitationtrainingonincompletespinalcordinjuryarandomizedclinicaltrial
AT liuyiwei effectofspecificacupuncturetherapycombinedwithrehabilitationtrainingonincompletespinalcordinjuryarandomizedclinicaltrial
AT lilingxin effectofspecificacupuncturetherapycombinedwithrehabilitationtrainingonincompletespinalcordinjuryarandomizedclinicaltrial
AT zhangrengang effectofspecificacupuncturetherapycombinedwithrehabilitationtrainingonincompletespinalcordinjuryarandomizedclinicaltrial
AT wangyulong effectofspecificacupuncturetherapycombinedwithrehabilitationtrainingonincompletespinalcordinjuryarandomizedclinicaltrial
AT hechengqi effectofspecificacupuncturetherapycombinedwithrehabilitationtrainingonincompletespinalcordinjuryarandomizedclinicaltrial
AT quanwei effectofspecificacupuncturetherapycombinedwithrehabilitationtrainingonincompletespinalcordinjuryarandomizedclinicaltrial