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Styrylchromones: Biological Activities and Structure-Activity Relationship
Styrylchromones (SC) are a group of oxygen-containing heterocyclic compounds, which are characterized by the attachment of a styryl group to the chromone core. SC can be found in nature or can be chemically synthesized in the laboratory. As their presence in nature is scarce, the synthetic origin is...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720608/ https://www.ncbi.nlm.nih.gov/pubmed/34987699 http://dx.doi.org/10.1155/2021/2804521 |
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author | Lucas, Mariana Freitas, Marisa Silva, Artur M. S. Fernandes, Eduarda Ribeiro, Daniela |
author_facet | Lucas, Mariana Freitas, Marisa Silva, Artur M. S. Fernandes, Eduarda Ribeiro, Daniela |
author_sort | Lucas, Mariana |
collection | PubMed |
description | Styrylchromones (SC) are a group of oxygen-containing heterocyclic compounds, which are characterized by the attachment of a styryl group to the chromone core. SC can be found in nature or can be chemically synthesized in the laboratory. As their presence in nature is scarce, the synthetic origin is the most common. Two types of SC are known: 2-styrylchromones and 3-styrylchromones. However, 2-styrylchromones are the most common, being more commonly found in nature and which chemical synthesis is more commonly described. A wide variety of SC has been described in the literature, with different substituents in different positions, the majority of which are distributed on the A- and/or B-rings. Over the years, several biological activities have been attributed to SC. This work presents a comprehensive review of the biological activities attributed to SC and their structure-activity relationship, based on a published literature search, since 1989. The following biological activities are thoroughly revised and discussed in this review: antioxidant, antiallergic, antiviral, antibacterial, antifungal, anti-inflammatory, and antitumoral, affinity and selectivity for A(3) adenosine receptors, neuroprotective, and α-glucosidase inhibition. In general, SC are composed by a promising scaffold with great potential for the development of new drugs. |
format | Online Article Text |
id | pubmed-8720608 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-87206082022-01-04 Styrylchromones: Biological Activities and Structure-Activity Relationship Lucas, Mariana Freitas, Marisa Silva, Artur M. S. Fernandes, Eduarda Ribeiro, Daniela Oxid Med Cell Longev Review Article Styrylchromones (SC) are a group of oxygen-containing heterocyclic compounds, which are characterized by the attachment of a styryl group to the chromone core. SC can be found in nature or can be chemically synthesized in the laboratory. As their presence in nature is scarce, the synthetic origin is the most common. Two types of SC are known: 2-styrylchromones and 3-styrylchromones. However, 2-styrylchromones are the most common, being more commonly found in nature and which chemical synthesis is more commonly described. A wide variety of SC has been described in the literature, with different substituents in different positions, the majority of which are distributed on the A- and/or B-rings. Over the years, several biological activities have been attributed to SC. This work presents a comprehensive review of the biological activities attributed to SC and their structure-activity relationship, based on a published literature search, since 1989. The following biological activities are thoroughly revised and discussed in this review: antioxidant, antiallergic, antiviral, antibacterial, antifungal, anti-inflammatory, and antitumoral, affinity and selectivity for A(3) adenosine receptors, neuroprotective, and α-glucosidase inhibition. In general, SC are composed by a promising scaffold with great potential for the development of new drugs. Hindawi 2021-12-22 /pmc/articles/PMC8720608/ /pubmed/34987699 http://dx.doi.org/10.1155/2021/2804521 Text en Copyright © 2021 Mariana Lucas et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Lucas, Mariana Freitas, Marisa Silva, Artur M. S. Fernandes, Eduarda Ribeiro, Daniela Styrylchromones: Biological Activities and Structure-Activity Relationship |
title | Styrylchromones: Biological Activities and Structure-Activity Relationship |
title_full | Styrylchromones: Biological Activities and Structure-Activity Relationship |
title_fullStr | Styrylchromones: Biological Activities and Structure-Activity Relationship |
title_full_unstemmed | Styrylchromones: Biological Activities and Structure-Activity Relationship |
title_short | Styrylchromones: Biological Activities and Structure-Activity Relationship |
title_sort | styrylchromones: biological activities and structure-activity relationship |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720608/ https://www.ncbi.nlm.nih.gov/pubmed/34987699 http://dx.doi.org/10.1155/2021/2804521 |
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