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A Case of Chorioretinitis with Retinal Angiomatous Proliferation

A 48-year-old woman had an acute blurred vision in the right eye immediately after drainage of liver abscess. Her best corrected visual acuity (BCVA) was 8/400; fundus photography suggested the diagnosis of endogenous endophthalmitis with chorioretinitis and vitritis. Due to the bad systemic conditi...

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Autores principales: Chen, Yanru, Wei, Mingyan, Chen, Qian, Li, Minghan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720613/
https://www.ncbi.nlm.nih.gov/pubmed/34987875
http://dx.doi.org/10.1155/2021/3564939
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author Chen, Yanru
Wei, Mingyan
Chen, Qian
Li, Minghan
author_facet Chen, Yanru
Wei, Mingyan
Chen, Qian
Li, Minghan
author_sort Chen, Yanru
collection PubMed
description A 48-year-old woman had an acute blurred vision in the right eye immediately after drainage of liver abscess. Her best corrected visual acuity (BCVA) was 8/400; fundus photography suggested the diagnosis of endogenous endophthalmitis with chorioretinitis and vitritis. Due to the bad systemic condition, a systemic antibiotic combined with periocular triamcinolone (TA) was carried out first. Inflammatory cells in the vitreous cavity were decreased after treatment; however, fundus fluorescein angiography (FFA) showed abnormal dilation and leakage of the capillaries and retinal-choroidal anastomose, supporting that there was retinal angiomatous proliferation (RAP). Vitreous interleukin-6 (IL-6) was only slightly elevated; the ratio of interleukin-10 (IL-10) and IL-6 was less than 1, and the etiological test was negative. After receiving intravitreal vancomycin injection combined with periocular TA injection, the patient's BCVA was improved from 16/400 to 20/400 with a reduction in vitreous inflammatory cells. However, the patient's RAP was progressed and her BCVA was dramatically decreased to count finger/30 cm. After intravitreal injection of ranibizumab, the patient's BCVA was 5/400 with a significant shrink in lesions and absorption of hemorrhage, exudation, and fluid. Thus, we suggest that early anti-inflammatory treatment in conjunction with anti-VEGF may achieve a better prognosis in patients with inflammatory retinal angiomatous proliferation (RAP).
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spelling pubmed-87206132022-01-04 A Case of Chorioretinitis with Retinal Angiomatous Proliferation Chen, Yanru Wei, Mingyan Chen, Qian Li, Minghan Case Rep Ophthalmol Med Case Report A 48-year-old woman had an acute blurred vision in the right eye immediately after drainage of liver abscess. Her best corrected visual acuity (BCVA) was 8/400; fundus photography suggested the diagnosis of endogenous endophthalmitis with chorioretinitis and vitritis. Due to the bad systemic condition, a systemic antibiotic combined with periocular triamcinolone (TA) was carried out first. Inflammatory cells in the vitreous cavity were decreased after treatment; however, fundus fluorescein angiography (FFA) showed abnormal dilation and leakage of the capillaries and retinal-choroidal anastomose, supporting that there was retinal angiomatous proliferation (RAP). Vitreous interleukin-6 (IL-6) was only slightly elevated; the ratio of interleukin-10 (IL-10) and IL-6 was less than 1, and the etiological test was negative. After receiving intravitreal vancomycin injection combined with periocular TA injection, the patient's BCVA was improved from 16/400 to 20/400 with a reduction in vitreous inflammatory cells. However, the patient's RAP was progressed and her BCVA was dramatically decreased to count finger/30 cm. After intravitreal injection of ranibizumab, the patient's BCVA was 5/400 with a significant shrink in lesions and absorption of hemorrhage, exudation, and fluid. Thus, we suggest that early anti-inflammatory treatment in conjunction with anti-VEGF may achieve a better prognosis in patients with inflammatory retinal angiomatous proliferation (RAP). Hindawi 2021-12-26 /pmc/articles/PMC8720613/ /pubmed/34987875 http://dx.doi.org/10.1155/2021/3564939 Text en Copyright © 2021 Yanru Chen et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Chen, Yanru
Wei, Mingyan
Chen, Qian
Li, Minghan
A Case of Chorioretinitis with Retinal Angiomatous Proliferation
title A Case of Chorioretinitis with Retinal Angiomatous Proliferation
title_full A Case of Chorioretinitis with Retinal Angiomatous Proliferation
title_fullStr A Case of Chorioretinitis with Retinal Angiomatous Proliferation
title_full_unstemmed A Case of Chorioretinitis with Retinal Angiomatous Proliferation
title_short A Case of Chorioretinitis with Retinal Angiomatous Proliferation
title_sort case of chorioretinitis with retinal angiomatous proliferation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720613/
https://www.ncbi.nlm.nih.gov/pubmed/34987875
http://dx.doi.org/10.1155/2021/3564939
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