Primary EWS/PNET of the lung with TP53 germline and SKT11 somatic mutation: A case report and review of the literature

Primary pulmonary EWS/PNET is extremely rare. This report describes a 20 year‐old man with primary pulmonary EWS/PNET with TP53 germline and SKT11 somatic mutation. After four neoadjuvant chemotherapy cycles (VAC with alternating IE) combined with anlotinib, a left pneumonectomy was performed. Maint...

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Autores principales: Zhang, Shuangping, Chen, Yun, Guo, Shiping, Chen, Ke‐Neng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720619/
https://www.ncbi.nlm.nih.gov/pubmed/34866350
http://dx.doi.org/10.1111/1759-7714.14251
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author Zhang, Shuangping
Chen, Yun
Guo, Shiping
Chen, Ke‐Neng
author_facet Zhang, Shuangping
Chen, Yun
Guo, Shiping
Chen, Ke‐Neng
author_sort Zhang, Shuangping
collection PubMed
description Primary pulmonary EWS/PNET is extremely rare. This report describes a 20 year‐old man with primary pulmonary EWS/PNET with TP53 germline and SKT11 somatic mutation. After four neoadjuvant chemotherapy cycles (VAC with alternating IE) combined with anlotinib, a left pneumonectomy was performed. Maintenance anlotinib monotherapy was then continued with no sign of recurrence to date. It is suggested that before the treatment and prognosis of children or young adults with primary EWS/PNET of the lung that consideration should be given to genetic testing.
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spelling pubmed-87206192022-01-07 Primary EWS/PNET of the lung with TP53 germline and SKT11 somatic mutation: A case report and review of the literature Zhang, Shuangping Chen, Yun Guo, Shiping Chen, Ke‐Neng Thorac Cancer Case Reports Primary pulmonary EWS/PNET is extremely rare. This report describes a 20 year‐old man with primary pulmonary EWS/PNET with TP53 germline and SKT11 somatic mutation. After four neoadjuvant chemotherapy cycles (VAC with alternating IE) combined with anlotinib, a left pneumonectomy was performed. Maintenance anlotinib monotherapy was then continued with no sign of recurrence to date. It is suggested that before the treatment and prognosis of children or young adults with primary EWS/PNET of the lung that consideration should be given to genetic testing. John Wiley & Sons Australia, Ltd 2021-12-05 2022-01 /pmc/articles/PMC8720619/ /pubmed/34866350 http://dx.doi.org/10.1111/1759-7714.14251 Text en © 2021 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Zhang, Shuangping
Chen, Yun
Guo, Shiping
Chen, Ke‐Neng
Primary EWS/PNET of the lung with TP53 germline and SKT11 somatic mutation: A case report and review of the literature
title Primary EWS/PNET of the lung with TP53 germline and SKT11 somatic mutation: A case report and review of the literature
title_full Primary EWS/PNET of the lung with TP53 germline and SKT11 somatic mutation: A case report and review of the literature
title_fullStr Primary EWS/PNET of the lung with TP53 germline and SKT11 somatic mutation: A case report and review of the literature
title_full_unstemmed Primary EWS/PNET of the lung with TP53 germline and SKT11 somatic mutation: A case report and review of the literature
title_short Primary EWS/PNET of the lung with TP53 germline and SKT11 somatic mutation: A case report and review of the literature
title_sort primary ews/pnet of the lung with tp53 germline and skt11 somatic mutation: a case report and review of the literature
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720619/
https://www.ncbi.nlm.nih.gov/pubmed/34866350
http://dx.doi.org/10.1111/1759-7714.14251
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