First successful case of platinum‐based chemotherapy for neuroendocrine prostate cancer with BRCA2 and PTEN alterations

INTRODUCTION: Deoxyribonucleic acid repair gene mutations are now being studied in a variety of solid tumors, with the hope of predicting prognosis, pathogenesis, and treatment outcomes. CASE PRESENTATION: We report the case of a Japanese patient with advanced castration‐resistant prostate cancer wh...

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Autores principales: Omura, Minami, Kosaka, Takeo, Aimono, Eriko, Nakamura, Kohei, Hongo, Hiroshi, Mikami, Shuji, Nishihara, Hiroshi, Oya, Mototsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720712/
https://www.ncbi.nlm.nih.gov/pubmed/35005470
http://dx.doi.org/10.1002/iju5.12383
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author Omura, Minami
Kosaka, Takeo
Aimono, Eriko
Nakamura, Kohei
Hongo, Hiroshi
Mikami, Shuji
Nishihara, Hiroshi
Oya, Mototsugu
author_facet Omura, Minami
Kosaka, Takeo
Aimono, Eriko
Nakamura, Kohei
Hongo, Hiroshi
Mikami, Shuji
Nishihara, Hiroshi
Oya, Mototsugu
author_sort Omura, Minami
collection PubMed
description INTRODUCTION: Deoxyribonucleic acid repair gene mutations are now being studied in a variety of solid tumors, with the hope of predicting prognosis, pathogenesis, and treatment outcomes. CASE PRESENTATION: We report the case of a Japanese patient with advanced castration‐resistant prostate cancer who exhibited a prominent response to platinum therapy and had coexisting BRCA2 and PTEN mutations according to retrospective multigene panel analysis. CONCLUSION: Through a review of clinical outcomes and genetic/pathologic profiling, the presented case provides insights into future management strategies based on the tumor genetic status.
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spelling pubmed-87207122022-01-07 First successful case of platinum‐based chemotherapy for neuroendocrine prostate cancer with BRCA2 and PTEN alterations Omura, Minami Kosaka, Takeo Aimono, Eriko Nakamura, Kohei Hongo, Hiroshi Mikami, Shuji Nishihara, Hiroshi Oya, Mototsugu IJU Case Rep Case Reports INTRODUCTION: Deoxyribonucleic acid repair gene mutations are now being studied in a variety of solid tumors, with the hope of predicting prognosis, pathogenesis, and treatment outcomes. CASE PRESENTATION: We report the case of a Japanese patient with advanced castration‐resistant prostate cancer who exhibited a prominent response to platinum therapy and had coexisting BRCA2 and PTEN mutations according to retrospective multigene panel analysis. CONCLUSION: Through a review of clinical outcomes and genetic/pathologic profiling, the presented case provides insights into future management strategies based on the tumor genetic status. John Wiley and Sons Inc. 2021-10-20 /pmc/articles/PMC8720712/ /pubmed/35005470 http://dx.doi.org/10.1002/iju5.12383 Text en © 2021 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of Japanese Urological Association https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Omura, Minami
Kosaka, Takeo
Aimono, Eriko
Nakamura, Kohei
Hongo, Hiroshi
Mikami, Shuji
Nishihara, Hiroshi
Oya, Mototsugu
First successful case of platinum‐based chemotherapy for neuroendocrine prostate cancer with BRCA2 and PTEN alterations
title First successful case of platinum‐based chemotherapy for neuroendocrine prostate cancer with BRCA2 and PTEN alterations
title_full First successful case of platinum‐based chemotherapy for neuroendocrine prostate cancer with BRCA2 and PTEN alterations
title_fullStr First successful case of platinum‐based chemotherapy for neuroendocrine prostate cancer with BRCA2 and PTEN alterations
title_full_unstemmed First successful case of platinum‐based chemotherapy for neuroendocrine prostate cancer with BRCA2 and PTEN alterations
title_short First successful case of platinum‐based chemotherapy for neuroendocrine prostate cancer with BRCA2 and PTEN alterations
title_sort first successful case of platinum‐based chemotherapy for neuroendocrine prostate cancer with brca2 and pten alterations
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720712/
https://www.ncbi.nlm.nih.gov/pubmed/35005470
http://dx.doi.org/10.1002/iju5.12383
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