Cargando…

Case Report: Pulmonary Conidiobolomycosis in a Vietnamese Pot-Bellied Pig

An adult castrated male Vietnamese pot-bellied pig had a 1-week history of acute dyspnea and lethargy. Minimal diagnostic testing was authorized by the owner, resulting in treatment with a third-generation cephalosporin and a non-steroidal anti-inflammatory drug. Partial improvement was observed aft...

Descripción completa

Detalles Bibliográficos
Autores principales: Rasche, Brittany L., Tucker, Samuel M., Linder, Keith, Harrison, Tara M., Negrão Watanabe, Tatiane Terumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720767/
https://www.ncbi.nlm.nih.gov/pubmed/34988143
http://dx.doi.org/10.3389/fvets.2021.799641
_version_ 1784625194029023232
author Rasche, Brittany L.
Tucker, Samuel M.
Linder, Keith
Harrison, Tara M.
Negrão Watanabe, Tatiane Terumi
author_facet Rasche, Brittany L.
Tucker, Samuel M.
Linder, Keith
Harrison, Tara M.
Negrão Watanabe, Tatiane Terumi
author_sort Rasche, Brittany L.
collection PubMed
description An adult castrated male Vietnamese pot-bellied pig had a 1-week history of acute dyspnea and lethargy. Minimal diagnostic testing was authorized by the owner, resulting in treatment with a third-generation cephalosporin and a non-steroidal anti-inflammatory drug. Partial improvement was observed after a week; however, the pig died 2 weeks after the initial onset of clinical signs. Macroscopically, ~90% of the left lung was effaced by large masses with a caseonecrotic center. Histologic examination revealed eosinophilic granulomas with myriad, intralesional, negatively staining hyphae highlighted by “sleeves” of hypereosinophilic material (Splendore-Hoeppli material). Infection with an oomycete or “zygomycete” (i.e., organisms of the order Entomophthorales or Mucorales) was initially considered. Pan-fungal PCR and sequencing performed on formalin-fixed, paraffin-embedded lung tissue identified Conidiobolus spp., consistent with a diagnosis of primary pulmonary conidiobolomycosis. There are only a few reports of infections with Conidiobolus spp. (and other members of the order Entomophthorales) in swine. Unlike humans and other animal species, conidiobolomycosis in pigs presents more commonly as a primary pulmonary disease rather than rhinofacial or nasopharyngeal disease.
format Online
Article
Text
id pubmed-8720767
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-87207672022-01-04 Case Report: Pulmonary Conidiobolomycosis in a Vietnamese Pot-Bellied Pig Rasche, Brittany L. Tucker, Samuel M. Linder, Keith Harrison, Tara M. Negrão Watanabe, Tatiane Terumi Front Vet Sci Veterinary Science An adult castrated male Vietnamese pot-bellied pig had a 1-week history of acute dyspnea and lethargy. Minimal diagnostic testing was authorized by the owner, resulting in treatment with a third-generation cephalosporin and a non-steroidal anti-inflammatory drug. Partial improvement was observed after a week; however, the pig died 2 weeks after the initial onset of clinical signs. Macroscopically, ~90% of the left lung was effaced by large masses with a caseonecrotic center. Histologic examination revealed eosinophilic granulomas with myriad, intralesional, negatively staining hyphae highlighted by “sleeves” of hypereosinophilic material (Splendore-Hoeppli material). Infection with an oomycete or “zygomycete” (i.e., organisms of the order Entomophthorales or Mucorales) was initially considered. Pan-fungal PCR and sequencing performed on formalin-fixed, paraffin-embedded lung tissue identified Conidiobolus spp., consistent with a diagnosis of primary pulmonary conidiobolomycosis. There are only a few reports of infections with Conidiobolus spp. (and other members of the order Entomophthorales) in swine. Unlike humans and other animal species, conidiobolomycosis in pigs presents more commonly as a primary pulmonary disease rather than rhinofacial or nasopharyngeal disease. Frontiers Media S.A. 2021-12-20 /pmc/articles/PMC8720767/ /pubmed/34988143 http://dx.doi.org/10.3389/fvets.2021.799641 Text en Copyright © 2021 Rasche, Tucker, Linder, Harrison and Negrão Watanabe. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Rasche, Brittany L.
Tucker, Samuel M.
Linder, Keith
Harrison, Tara M.
Negrão Watanabe, Tatiane Terumi
Case Report: Pulmonary Conidiobolomycosis in a Vietnamese Pot-Bellied Pig
title Case Report: Pulmonary Conidiobolomycosis in a Vietnamese Pot-Bellied Pig
title_full Case Report: Pulmonary Conidiobolomycosis in a Vietnamese Pot-Bellied Pig
title_fullStr Case Report: Pulmonary Conidiobolomycosis in a Vietnamese Pot-Bellied Pig
title_full_unstemmed Case Report: Pulmonary Conidiobolomycosis in a Vietnamese Pot-Bellied Pig
title_short Case Report: Pulmonary Conidiobolomycosis in a Vietnamese Pot-Bellied Pig
title_sort case report: pulmonary conidiobolomycosis in a vietnamese pot-bellied pig
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720767/
https://www.ncbi.nlm.nih.gov/pubmed/34988143
http://dx.doi.org/10.3389/fvets.2021.799641
work_keys_str_mv AT raschebrittanyl casereportpulmonaryconidiobolomycosisinavietnamesepotbelliedpig
AT tuckersamuelm casereportpulmonaryconidiobolomycosisinavietnamesepotbelliedpig
AT linderkeith casereportpulmonaryconidiobolomycosisinavietnamesepotbelliedpig
AT harrisontaram casereportpulmonaryconidiobolomycosisinavietnamesepotbelliedpig
AT negraowatanabetatianeterumi casereportpulmonaryconidiobolomycosisinavietnamesepotbelliedpig