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Case Report: Pulmonary Conidiobolomycosis in a Vietnamese Pot-Bellied Pig
An adult castrated male Vietnamese pot-bellied pig had a 1-week history of acute dyspnea and lethargy. Minimal diagnostic testing was authorized by the owner, resulting in treatment with a third-generation cephalosporin and a non-steroidal anti-inflammatory drug. Partial improvement was observed aft...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720767/ https://www.ncbi.nlm.nih.gov/pubmed/34988143 http://dx.doi.org/10.3389/fvets.2021.799641 |
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author | Rasche, Brittany L. Tucker, Samuel M. Linder, Keith Harrison, Tara M. Negrão Watanabe, Tatiane Terumi |
author_facet | Rasche, Brittany L. Tucker, Samuel M. Linder, Keith Harrison, Tara M. Negrão Watanabe, Tatiane Terumi |
author_sort | Rasche, Brittany L. |
collection | PubMed |
description | An adult castrated male Vietnamese pot-bellied pig had a 1-week history of acute dyspnea and lethargy. Minimal diagnostic testing was authorized by the owner, resulting in treatment with a third-generation cephalosporin and a non-steroidal anti-inflammatory drug. Partial improvement was observed after a week; however, the pig died 2 weeks after the initial onset of clinical signs. Macroscopically, ~90% of the left lung was effaced by large masses with a caseonecrotic center. Histologic examination revealed eosinophilic granulomas with myriad, intralesional, negatively staining hyphae highlighted by “sleeves” of hypereosinophilic material (Splendore-Hoeppli material). Infection with an oomycete or “zygomycete” (i.e., organisms of the order Entomophthorales or Mucorales) was initially considered. Pan-fungal PCR and sequencing performed on formalin-fixed, paraffin-embedded lung tissue identified Conidiobolus spp., consistent with a diagnosis of primary pulmonary conidiobolomycosis. There are only a few reports of infections with Conidiobolus spp. (and other members of the order Entomophthorales) in swine. Unlike humans and other animal species, conidiobolomycosis in pigs presents more commonly as a primary pulmonary disease rather than rhinofacial or nasopharyngeal disease. |
format | Online Article Text |
id | pubmed-8720767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87207672022-01-04 Case Report: Pulmonary Conidiobolomycosis in a Vietnamese Pot-Bellied Pig Rasche, Brittany L. Tucker, Samuel M. Linder, Keith Harrison, Tara M. Negrão Watanabe, Tatiane Terumi Front Vet Sci Veterinary Science An adult castrated male Vietnamese pot-bellied pig had a 1-week history of acute dyspnea and lethargy. Minimal diagnostic testing was authorized by the owner, resulting in treatment with a third-generation cephalosporin and a non-steroidal anti-inflammatory drug. Partial improvement was observed after a week; however, the pig died 2 weeks after the initial onset of clinical signs. Macroscopically, ~90% of the left lung was effaced by large masses with a caseonecrotic center. Histologic examination revealed eosinophilic granulomas with myriad, intralesional, negatively staining hyphae highlighted by “sleeves” of hypereosinophilic material (Splendore-Hoeppli material). Infection with an oomycete or “zygomycete” (i.e., organisms of the order Entomophthorales or Mucorales) was initially considered. Pan-fungal PCR and sequencing performed on formalin-fixed, paraffin-embedded lung tissue identified Conidiobolus spp., consistent with a diagnosis of primary pulmonary conidiobolomycosis. There are only a few reports of infections with Conidiobolus spp. (and other members of the order Entomophthorales) in swine. Unlike humans and other animal species, conidiobolomycosis in pigs presents more commonly as a primary pulmonary disease rather than rhinofacial or nasopharyngeal disease. Frontiers Media S.A. 2021-12-20 /pmc/articles/PMC8720767/ /pubmed/34988143 http://dx.doi.org/10.3389/fvets.2021.799641 Text en Copyright © 2021 Rasche, Tucker, Linder, Harrison and Negrão Watanabe. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Veterinary Science Rasche, Brittany L. Tucker, Samuel M. Linder, Keith Harrison, Tara M. Negrão Watanabe, Tatiane Terumi Case Report: Pulmonary Conidiobolomycosis in a Vietnamese Pot-Bellied Pig |
title | Case Report: Pulmonary Conidiobolomycosis in a Vietnamese Pot-Bellied Pig |
title_full | Case Report: Pulmonary Conidiobolomycosis in a Vietnamese Pot-Bellied Pig |
title_fullStr | Case Report: Pulmonary Conidiobolomycosis in a Vietnamese Pot-Bellied Pig |
title_full_unstemmed | Case Report: Pulmonary Conidiobolomycosis in a Vietnamese Pot-Bellied Pig |
title_short | Case Report: Pulmonary Conidiobolomycosis in a Vietnamese Pot-Bellied Pig |
title_sort | case report: pulmonary conidiobolomycosis in a vietnamese pot-bellied pig |
topic | Veterinary Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720767/ https://www.ncbi.nlm.nih.gov/pubmed/34988143 http://dx.doi.org/10.3389/fvets.2021.799641 |
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