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The Similarities and Differences Between Glomerular vs. Non-glomerular Diagnoses on Intelligence and Executive Functions in Pediatric Chronic Kidney Disease: A Brief Report

Pediatric chronic kidney disease (CKD) appears to be a heterogeneous group of conditions, but this heterogeneity has not been explored with respect to its impact on neurocognitive functioning. This study investigated the neurocognitive functioning of those with glomerular (G) vs. non-glomerular (NG)...

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Autores principales: Hooper, Stephen R., Johnson, Rebecca J., Lande, Marc, Matheson, Matthew, Shinnar, Shlomo, Kogon, Amy J., Harshman, Lyndsay, Spinale, Joann, Gerson, Arlene C., Warady, Bradley A., Furth, Susan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720880/
https://www.ncbi.nlm.nih.gov/pubmed/34987470
http://dx.doi.org/10.3389/fneur.2021.787602
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author Hooper, Stephen R.
Johnson, Rebecca J.
Lande, Marc
Matheson, Matthew
Shinnar, Shlomo
Kogon, Amy J.
Harshman, Lyndsay
Spinale, Joann
Gerson, Arlene C.
Warady, Bradley A.
Furth, Susan L.
author_facet Hooper, Stephen R.
Johnson, Rebecca J.
Lande, Marc
Matheson, Matthew
Shinnar, Shlomo
Kogon, Amy J.
Harshman, Lyndsay
Spinale, Joann
Gerson, Arlene C.
Warady, Bradley A.
Furth, Susan L.
author_sort Hooper, Stephen R.
collection PubMed
description Pediatric chronic kidney disease (CKD) appears to be a heterogeneous group of conditions, but this heterogeneity has not been explored with respect to its impact on neurocognitive functioning. This study investigated the neurocognitive functioning of those with glomerular (G) vs. non-glomerular (NG) diagnoses. Data from the North American CKiD Study were employed and the current study included 1,003 children and adolescents with mild to moderate CKD. The G Group included 260 participants (median age = 14.7 years) and the NG Group included 743 individuals (median age = 9.0 years). Neurocognitive measures assessed IQ, inhibitory control, attention regulation, problem solving, working memory, and overall executive functioning. Data from all visits were included in the linear mixed model analyses. After adjusting for sociodemographic and CKD-related covariates, results indicated no differences between the diagnostic groups on measures of IQ, problem solving, working memory, and attention regulation. There was a trend for the G group to receive better parent ratings on their overall executive functions (p < 0.07), with a small effect size being present. Additionally, there was a significant G group X hypertension interaction (p < 0.003) for inhibitory control, indicating that those with both a G diagnosis and hypertension performed more poorly than the NG group with hypertension. These findings suggest that the separation of G vs. NG CKD produced minimal, but specific group differences were observed. Ongoing examination of the heterogeneity of pediatric CKD on neurocognition, perhaps at a different time point in disease progression or using a different model, appears warranted.
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spelling pubmed-87208802022-01-04 The Similarities and Differences Between Glomerular vs. Non-glomerular Diagnoses on Intelligence and Executive Functions in Pediatric Chronic Kidney Disease: A Brief Report Hooper, Stephen R. Johnson, Rebecca J. Lande, Marc Matheson, Matthew Shinnar, Shlomo Kogon, Amy J. Harshman, Lyndsay Spinale, Joann Gerson, Arlene C. Warady, Bradley A. Furth, Susan L. Front Neurol Neurology Pediatric chronic kidney disease (CKD) appears to be a heterogeneous group of conditions, but this heterogeneity has not been explored with respect to its impact on neurocognitive functioning. This study investigated the neurocognitive functioning of those with glomerular (G) vs. non-glomerular (NG) diagnoses. Data from the North American CKiD Study were employed and the current study included 1,003 children and adolescents with mild to moderate CKD. The G Group included 260 participants (median age = 14.7 years) and the NG Group included 743 individuals (median age = 9.0 years). Neurocognitive measures assessed IQ, inhibitory control, attention regulation, problem solving, working memory, and overall executive functioning. Data from all visits were included in the linear mixed model analyses. After adjusting for sociodemographic and CKD-related covariates, results indicated no differences between the diagnostic groups on measures of IQ, problem solving, working memory, and attention regulation. There was a trend for the G group to receive better parent ratings on their overall executive functions (p < 0.07), with a small effect size being present. Additionally, there was a significant G group X hypertension interaction (p < 0.003) for inhibitory control, indicating that those with both a G diagnosis and hypertension performed more poorly than the NG group with hypertension. These findings suggest that the separation of G vs. NG CKD produced minimal, but specific group differences were observed. Ongoing examination of the heterogeneity of pediatric CKD on neurocognition, perhaps at a different time point in disease progression or using a different model, appears warranted. Frontiers Media S.A. 2021-12-20 /pmc/articles/PMC8720880/ /pubmed/34987470 http://dx.doi.org/10.3389/fneur.2021.787602 Text en Copyright © 2021 Hooper, Johnson, Lande, Matheson, Shinnar, Kogon, Harshman, Spinale, Gerson, Warady and Furth. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Hooper, Stephen R.
Johnson, Rebecca J.
Lande, Marc
Matheson, Matthew
Shinnar, Shlomo
Kogon, Amy J.
Harshman, Lyndsay
Spinale, Joann
Gerson, Arlene C.
Warady, Bradley A.
Furth, Susan L.
The Similarities and Differences Between Glomerular vs. Non-glomerular Diagnoses on Intelligence and Executive Functions in Pediatric Chronic Kidney Disease: A Brief Report
title The Similarities and Differences Between Glomerular vs. Non-glomerular Diagnoses on Intelligence and Executive Functions in Pediatric Chronic Kidney Disease: A Brief Report
title_full The Similarities and Differences Between Glomerular vs. Non-glomerular Diagnoses on Intelligence and Executive Functions in Pediatric Chronic Kidney Disease: A Brief Report
title_fullStr The Similarities and Differences Between Glomerular vs. Non-glomerular Diagnoses on Intelligence and Executive Functions in Pediatric Chronic Kidney Disease: A Brief Report
title_full_unstemmed The Similarities and Differences Between Glomerular vs. Non-glomerular Diagnoses on Intelligence and Executive Functions in Pediatric Chronic Kidney Disease: A Brief Report
title_short The Similarities and Differences Between Glomerular vs. Non-glomerular Diagnoses on Intelligence and Executive Functions in Pediatric Chronic Kidney Disease: A Brief Report
title_sort similarities and differences between glomerular vs. non-glomerular diagnoses on intelligence and executive functions in pediatric chronic kidney disease: a brief report
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720880/
https://www.ncbi.nlm.nih.gov/pubmed/34987470
http://dx.doi.org/10.3389/fneur.2021.787602
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