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The Roles of Cardiovascular H(2)-Histamine Receptors Under Normal and Pathophysiological Conditions

This review addresses pharmacological, structural and functional relationships among H(2)-histamine receptors and H(1)-histamine receptors in the mammalian heart. The role of both receptors in the regulation of force and rhythm, including their electrophysiological effects on the mammalian heart, wi...

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Autores principales: Neumann, Joachim, Kirchhefer, Uwe, Dhein, Stefan, Hofmann, Britt, Gergs, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720924/
https://www.ncbi.nlm.nih.gov/pubmed/34987383
http://dx.doi.org/10.3389/fphar.2021.732842
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author Neumann, Joachim
Kirchhefer, Uwe
Dhein, Stefan
Hofmann, Britt
Gergs, Ulrich
author_facet Neumann, Joachim
Kirchhefer, Uwe
Dhein, Stefan
Hofmann, Britt
Gergs, Ulrich
author_sort Neumann, Joachim
collection PubMed
description This review addresses pharmacological, structural and functional relationships among H(2)-histamine receptors and H(1)-histamine receptors in the mammalian heart. The role of both receptors in the regulation of force and rhythm, including their electrophysiological effects on the mammalian heart, will then be discussed in context. The potential clinical role of cardiac H(2)-histamine-receptors in cardiac diseases will be examined. The use of H(2)-histamine receptor agonists to acutely increase the force of contraction will be discussed. Special attention will be paid to the potential role of cardiac H(2)-histamine receptors in the genesis of cardiac arrhythmias. Moreover, novel findings on the putative role of H(2)-histamine receptor antagonists in treating chronic heart failure in animal models and patients will be reviewed. Some limitations in our biochemical understanding of the cardiac role of H(2)-histamine receptors will be discussed. Recommendations for further basic and translational research on cardiac H(2)-histamine receptors will be offered. We will speculate whether new knowledge might lead to novel roles of H(2)-histamine receptors in cardiac disease and whether cardiomyocyte specific H(2)-histamine receptor agonists and antagonists should be developed.
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spelling pubmed-87209242022-01-04 The Roles of Cardiovascular H(2)-Histamine Receptors Under Normal and Pathophysiological Conditions Neumann, Joachim Kirchhefer, Uwe Dhein, Stefan Hofmann, Britt Gergs, Ulrich Front Pharmacol Pharmacology This review addresses pharmacological, structural and functional relationships among H(2)-histamine receptors and H(1)-histamine receptors in the mammalian heart. The role of both receptors in the regulation of force and rhythm, including their electrophysiological effects on the mammalian heart, will then be discussed in context. The potential clinical role of cardiac H(2)-histamine-receptors in cardiac diseases will be examined. The use of H(2)-histamine receptor agonists to acutely increase the force of contraction will be discussed. Special attention will be paid to the potential role of cardiac H(2)-histamine receptors in the genesis of cardiac arrhythmias. Moreover, novel findings on the putative role of H(2)-histamine receptor antagonists in treating chronic heart failure in animal models and patients will be reviewed. Some limitations in our biochemical understanding of the cardiac role of H(2)-histamine receptors will be discussed. Recommendations for further basic and translational research on cardiac H(2)-histamine receptors will be offered. We will speculate whether new knowledge might lead to novel roles of H(2)-histamine receptors in cardiac disease and whether cardiomyocyte specific H(2)-histamine receptor agonists and antagonists should be developed. Frontiers Media S.A. 2021-12-20 /pmc/articles/PMC8720924/ /pubmed/34987383 http://dx.doi.org/10.3389/fphar.2021.732842 Text en Copyright © 2021 Neumann, Kirchhefer, Dhein, Hofmann and Gergs. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Neumann, Joachim
Kirchhefer, Uwe
Dhein, Stefan
Hofmann, Britt
Gergs, Ulrich
The Roles of Cardiovascular H(2)-Histamine Receptors Under Normal and Pathophysiological Conditions
title The Roles of Cardiovascular H(2)-Histamine Receptors Under Normal and Pathophysiological Conditions
title_full The Roles of Cardiovascular H(2)-Histamine Receptors Under Normal and Pathophysiological Conditions
title_fullStr The Roles of Cardiovascular H(2)-Histamine Receptors Under Normal and Pathophysiological Conditions
title_full_unstemmed The Roles of Cardiovascular H(2)-Histamine Receptors Under Normal and Pathophysiological Conditions
title_short The Roles of Cardiovascular H(2)-Histamine Receptors Under Normal and Pathophysiological Conditions
title_sort roles of cardiovascular h(2)-histamine receptors under normal and pathophysiological conditions
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720924/
https://www.ncbi.nlm.nih.gov/pubmed/34987383
http://dx.doi.org/10.3389/fphar.2021.732842
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