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The Roles of Cardiovascular H(2)-Histamine Receptors Under Normal and Pathophysiological Conditions
This review addresses pharmacological, structural and functional relationships among H(2)-histamine receptors and H(1)-histamine receptors in the mammalian heart. The role of both receptors in the regulation of force and rhythm, including their electrophysiological effects on the mammalian heart, wi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720924/ https://www.ncbi.nlm.nih.gov/pubmed/34987383 http://dx.doi.org/10.3389/fphar.2021.732842 |
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author | Neumann, Joachim Kirchhefer, Uwe Dhein, Stefan Hofmann, Britt Gergs, Ulrich |
author_facet | Neumann, Joachim Kirchhefer, Uwe Dhein, Stefan Hofmann, Britt Gergs, Ulrich |
author_sort | Neumann, Joachim |
collection | PubMed |
description | This review addresses pharmacological, structural and functional relationships among H(2)-histamine receptors and H(1)-histamine receptors in the mammalian heart. The role of both receptors in the regulation of force and rhythm, including their electrophysiological effects on the mammalian heart, will then be discussed in context. The potential clinical role of cardiac H(2)-histamine-receptors in cardiac diseases will be examined. The use of H(2)-histamine receptor agonists to acutely increase the force of contraction will be discussed. Special attention will be paid to the potential role of cardiac H(2)-histamine receptors in the genesis of cardiac arrhythmias. Moreover, novel findings on the putative role of H(2)-histamine receptor antagonists in treating chronic heart failure in animal models and patients will be reviewed. Some limitations in our biochemical understanding of the cardiac role of H(2)-histamine receptors will be discussed. Recommendations for further basic and translational research on cardiac H(2)-histamine receptors will be offered. We will speculate whether new knowledge might lead to novel roles of H(2)-histamine receptors in cardiac disease and whether cardiomyocyte specific H(2)-histamine receptor agonists and antagonists should be developed. |
format | Online Article Text |
id | pubmed-8720924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87209242022-01-04 The Roles of Cardiovascular H(2)-Histamine Receptors Under Normal and Pathophysiological Conditions Neumann, Joachim Kirchhefer, Uwe Dhein, Stefan Hofmann, Britt Gergs, Ulrich Front Pharmacol Pharmacology This review addresses pharmacological, structural and functional relationships among H(2)-histamine receptors and H(1)-histamine receptors in the mammalian heart. The role of both receptors in the regulation of force and rhythm, including their electrophysiological effects on the mammalian heart, will then be discussed in context. The potential clinical role of cardiac H(2)-histamine-receptors in cardiac diseases will be examined. The use of H(2)-histamine receptor agonists to acutely increase the force of contraction will be discussed. Special attention will be paid to the potential role of cardiac H(2)-histamine receptors in the genesis of cardiac arrhythmias. Moreover, novel findings on the putative role of H(2)-histamine receptor antagonists in treating chronic heart failure in animal models and patients will be reviewed. Some limitations in our biochemical understanding of the cardiac role of H(2)-histamine receptors will be discussed. Recommendations for further basic and translational research on cardiac H(2)-histamine receptors will be offered. We will speculate whether new knowledge might lead to novel roles of H(2)-histamine receptors in cardiac disease and whether cardiomyocyte specific H(2)-histamine receptor agonists and antagonists should be developed. Frontiers Media S.A. 2021-12-20 /pmc/articles/PMC8720924/ /pubmed/34987383 http://dx.doi.org/10.3389/fphar.2021.732842 Text en Copyright © 2021 Neumann, Kirchhefer, Dhein, Hofmann and Gergs. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Neumann, Joachim Kirchhefer, Uwe Dhein, Stefan Hofmann, Britt Gergs, Ulrich The Roles of Cardiovascular H(2)-Histamine Receptors Under Normal and Pathophysiological Conditions |
title | The Roles of Cardiovascular H(2)-Histamine Receptors Under Normal and Pathophysiological Conditions |
title_full | The Roles of Cardiovascular H(2)-Histamine Receptors Under Normal and Pathophysiological Conditions |
title_fullStr | The Roles of Cardiovascular H(2)-Histamine Receptors Under Normal and Pathophysiological Conditions |
title_full_unstemmed | The Roles of Cardiovascular H(2)-Histamine Receptors Under Normal and Pathophysiological Conditions |
title_short | The Roles of Cardiovascular H(2)-Histamine Receptors Under Normal and Pathophysiological Conditions |
title_sort | roles of cardiovascular h(2)-histamine receptors under normal and pathophysiological conditions |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720924/ https://www.ncbi.nlm.nih.gov/pubmed/34987383 http://dx.doi.org/10.3389/fphar.2021.732842 |
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