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Treatment of Inflammatory Bowel Disease: A Comprehensive Review

Inflammatory bowel disease (IBD), as a global disease, has attracted much research interest. Constant research has led to a better understanding of the disease condition and further promoted its management. We here reviewed the conventional and the novel drugs and therapies, as well as the potential...

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Detalles Bibliográficos
Autores principales: Cai, Zhaobei, Wang, Shu, Li, Jiannan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720971/
https://www.ncbi.nlm.nih.gov/pubmed/34988090
http://dx.doi.org/10.3389/fmed.2021.765474
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author Cai, Zhaobei
Wang, Shu
Li, Jiannan
author_facet Cai, Zhaobei
Wang, Shu
Li, Jiannan
author_sort Cai, Zhaobei
collection PubMed
description Inflammatory bowel disease (IBD), as a global disease, has attracted much research interest. Constant research has led to a better understanding of the disease condition and further promoted its management. We here reviewed the conventional and the novel drugs and therapies, as well as the potential ones, which have shown promise in preclinical studies and are likely to be effective future therapies. The conventional treatments aim at controlling symptoms through pharmacotherapy, including aminosalicylates, corticosteroids, immunomodulators, and biologics, with other general measures and/or surgical resection if necessary. However, a considerable fraction of patients do not respond to available treatments or lose response, which calls for new therapeutic strategies. Diverse therapeutic options are emerging, involving small molecules, apheresis therapy, improved intestinal microecology, cell therapy, and exosome therapy. In addition, patient education partly upgrades the efficacy of IBD treatment. Recent advances in the management of IBD have led to a paradigm shift in the treatment goals, from targeting symptom-free daily life to shooting for mucosal healing. In this review, the latest progress in IBD treatment is summarized to understand the advantages, pitfalls, and research prospects of different drugs and therapies and to provide a basis for the clinical decision and further research of IBD.
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spelling pubmed-87209712022-01-04 Treatment of Inflammatory Bowel Disease: A Comprehensive Review Cai, Zhaobei Wang, Shu Li, Jiannan Front Med (Lausanne) Medicine Inflammatory bowel disease (IBD), as a global disease, has attracted much research interest. Constant research has led to a better understanding of the disease condition and further promoted its management. We here reviewed the conventional and the novel drugs and therapies, as well as the potential ones, which have shown promise in preclinical studies and are likely to be effective future therapies. The conventional treatments aim at controlling symptoms through pharmacotherapy, including aminosalicylates, corticosteroids, immunomodulators, and biologics, with other general measures and/or surgical resection if necessary. However, a considerable fraction of patients do not respond to available treatments or lose response, which calls for new therapeutic strategies. Diverse therapeutic options are emerging, involving small molecules, apheresis therapy, improved intestinal microecology, cell therapy, and exosome therapy. In addition, patient education partly upgrades the efficacy of IBD treatment. Recent advances in the management of IBD have led to a paradigm shift in the treatment goals, from targeting symptom-free daily life to shooting for mucosal healing. In this review, the latest progress in IBD treatment is summarized to understand the advantages, pitfalls, and research prospects of different drugs and therapies and to provide a basis for the clinical decision and further research of IBD. Frontiers Media S.A. 2021-12-20 /pmc/articles/PMC8720971/ /pubmed/34988090 http://dx.doi.org/10.3389/fmed.2021.765474 Text en Copyright © 2021 Cai, Wang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Cai, Zhaobei
Wang, Shu
Li, Jiannan
Treatment of Inflammatory Bowel Disease: A Comprehensive Review
title Treatment of Inflammatory Bowel Disease: A Comprehensive Review
title_full Treatment of Inflammatory Bowel Disease: A Comprehensive Review
title_fullStr Treatment of Inflammatory Bowel Disease: A Comprehensive Review
title_full_unstemmed Treatment of Inflammatory Bowel Disease: A Comprehensive Review
title_short Treatment of Inflammatory Bowel Disease: A Comprehensive Review
title_sort treatment of inflammatory bowel disease: a comprehensive review
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720971/
https://www.ncbi.nlm.nih.gov/pubmed/34988090
http://dx.doi.org/10.3389/fmed.2021.765474
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