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Treatment of Inflammatory Bowel Disease: A Comprehensive Review
Inflammatory bowel disease (IBD), as a global disease, has attracted much research interest. Constant research has led to a better understanding of the disease condition and further promoted its management. We here reviewed the conventional and the novel drugs and therapies, as well as the potential...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720971/ https://www.ncbi.nlm.nih.gov/pubmed/34988090 http://dx.doi.org/10.3389/fmed.2021.765474 |
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author | Cai, Zhaobei Wang, Shu Li, Jiannan |
author_facet | Cai, Zhaobei Wang, Shu Li, Jiannan |
author_sort | Cai, Zhaobei |
collection | PubMed |
description | Inflammatory bowel disease (IBD), as a global disease, has attracted much research interest. Constant research has led to a better understanding of the disease condition and further promoted its management. We here reviewed the conventional and the novel drugs and therapies, as well as the potential ones, which have shown promise in preclinical studies and are likely to be effective future therapies. The conventional treatments aim at controlling symptoms through pharmacotherapy, including aminosalicylates, corticosteroids, immunomodulators, and biologics, with other general measures and/or surgical resection if necessary. However, a considerable fraction of patients do not respond to available treatments or lose response, which calls for new therapeutic strategies. Diverse therapeutic options are emerging, involving small molecules, apheresis therapy, improved intestinal microecology, cell therapy, and exosome therapy. In addition, patient education partly upgrades the efficacy of IBD treatment. Recent advances in the management of IBD have led to a paradigm shift in the treatment goals, from targeting symptom-free daily life to shooting for mucosal healing. In this review, the latest progress in IBD treatment is summarized to understand the advantages, pitfalls, and research prospects of different drugs and therapies and to provide a basis for the clinical decision and further research of IBD. |
format | Online Article Text |
id | pubmed-8720971 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87209712022-01-04 Treatment of Inflammatory Bowel Disease: A Comprehensive Review Cai, Zhaobei Wang, Shu Li, Jiannan Front Med (Lausanne) Medicine Inflammatory bowel disease (IBD), as a global disease, has attracted much research interest. Constant research has led to a better understanding of the disease condition and further promoted its management. We here reviewed the conventional and the novel drugs and therapies, as well as the potential ones, which have shown promise in preclinical studies and are likely to be effective future therapies. The conventional treatments aim at controlling symptoms through pharmacotherapy, including aminosalicylates, corticosteroids, immunomodulators, and biologics, with other general measures and/or surgical resection if necessary. However, a considerable fraction of patients do not respond to available treatments or lose response, which calls for new therapeutic strategies. Diverse therapeutic options are emerging, involving small molecules, apheresis therapy, improved intestinal microecology, cell therapy, and exosome therapy. In addition, patient education partly upgrades the efficacy of IBD treatment. Recent advances in the management of IBD have led to a paradigm shift in the treatment goals, from targeting symptom-free daily life to shooting for mucosal healing. In this review, the latest progress in IBD treatment is summarized to understand the advantages, pitfalls, and research prospects of different drugs and therapies and to provide a basis for the clinical decision and further research of IBD. Frontiers Media S.A. 2021-12-20 /pmc/articles/PMC8720971/ /pubmed/34988090 http://dx.doi.org/10.3389/fmed.2021.765474 Text en Copyright © 2021 Cai, Wang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Cai, Zhaobei Wang, Shu Li, Jiannan Treatment of Inflammatory Bowel Disease: A Comprehensive Review |
title | Treatment of Inflammatory Bowel Disease: A Comprehensive Review |
title_full | Treatment of Inflammatory Bowel Disease: A Comprehensive Review |
title_fullStr | Treatment of Inflammatory Bowel Disease: A Comprehensive Review |
title_full_unstemmed | Treatment of Inflammatory Bowel Disease: A Comprehensive Review |
title_short | Treatment of Inflammatory Bowel Disease: A Comprehensive Review |
title_sort | treatment of inflammatory bowel disease: a comprehensive review |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720971/ https://www.ncbi.nlm.nih.gov/pubmed/34988090 http://dx.doi.org/10.3389/fmed.2021.765474 |
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