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Loss of PDK1 Induces Meiotic Defects in Oocytes From Diabetic Mice

Maternal diabetes has been shown to impair oocyte quality; however, the underlying mechanisms remain unclear. Here, using a streptozotocin (STZ)-induced diabetic mouse model, we first detected and reduced expression of pyruvate dehydrogenase kinase 1 (PDK1) in diabetic oocytes, accompanying with the...

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Detalles Bibliográficos
Autores principales:	Ge, Juan, Zhang, Na, Tang, Shoubin, Hu, Feifei, Hou, Xiaojing, Sun, Hongzheng, Han, Longsen, Wang, Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720995/ https://www.ncbi.nlm.nih.gov/pubmed/34988082 http://dx.doi.org/10.3389/fcell.2021.793389

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