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Current Research Progress of the Role of LncRNA LEF1-AS1 in a Variety of Tumors

Long non-coding RNAs (lncRNA), as key regulators of cell proliferation and death, are involved in the regulation of various processes in the nucleus and cytoplasm, involving biological developmental processes in the fields of immunology, neurobiology, cancer, and stress. There is great scientific in...

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Autores principales: Zheng, Qingyuan, Yu, Xiao, Zhang, Menggang, Zhang, Shuijun, Guo, Wenzhi, He, Yuting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721001/
https://www.ncbi.nlm.nih.gov/pubmed/34988073
http://dx.doi.org/10.3389/fcell.2021.750084
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author Zheng, Qingyuan
Yu, Xiao
Zhang, Menggang
Zhang, Shuijun
Guo, Wenzhi
He, Yuting
author_facet Zheng, Qingyuan
Yu, Xiao
Zhang, Menggang
Zhang, Shuijun
Guo, Wenzhi
He, Yuting
author_sort Zheng, Qingyuan
collection PubMed
description Long non-coding RNAs (lncRNA), as key regulators of cell proliferation and death, are involved in the regulation of various processes in the nucleus and cytoplasm, involving biological developmental processes in the fields of immunology, neurobiology, cancer, and stress. There is great scientific interest in exploring the relationship between lncRNA and tumors. Many researches revealed that lymph enhancer-binding factor 1-antisense RNA 1 (LEF1-AS1), a recently discovered lncRNA, is downregulated in myeloid malignancy, acting mainly as a tumor suppressor, while it is highly expressed and carcinogenic in glioblastoma (GBM), lung cancer, hepatocellular carcinoma (HCC), osteosarcoma, colorectal cancer (CRC), oral squamous cell carcinoma (OSCC), prostatic carcinoma, retinoblastoma, and other malignant tumors. Furthermore, abnormal LEF1-AS1 expression was associated with tumorigenesis, development, survival, and prognosis via the regulation of target genes and signaling pathways. This review summarizes the existing data on the expression, functions, underlying mechanism, relevant signaling pathways, and clinical significance of LEF1-AS1 in cancer. It is concluded that LEF1-AS1 can serve as a novel biomarker for the diagnosis and prognosis of various tumors, thus deserves further attention in the future.
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spelling pubmed-87210012022-01-04 Current Research Progress of the Role of LncRNA LEF1-AS1 in a Variety of Tumors Zheng, Qingyuan Yu, Xiao Zhang, Menggang Zhang, Shuijun Guo, Wenzhi He, Yuting Front Cell Dev Biol Cell and Developmental Biology Long non-coding RNAs (lncRNA), as key regulators of cell proliferation and death, are involved in the regulation of various processes in the nucleus and cytoplasm, involving biological developmental processes in the fields of immunology, neurobiology, cancer, and stress. There is great scientific interest in exploring the relationship between lncRNA and tumors. Many researches revealed that lymph enhancer-binding factor 1-antisense RNA 1 (LEF1-AS1), a recently discovered lncRNA, is downregulated in myeloid malignancy, acting mainly as a tumor suppressor, while it is highly expressed and carcinogenic in glioblastoma (GBM), lung cancer, hepatocellular carcinoma (HCC), osteosarcoma, colorectal cancer (CRC), oral squamous cell carcinoma (OSCC), prostatic carcinoma, retinoblastoma, and other malignant tumors. Furthermore, abnormal LEF1-AS1 expression was associated with tumorigenesis, development, survival, and prognosis via the regulation of target genes and signaling pathways. This review summarizes the existing data on the expression, functions, underlying mechanism, relevant signaling pathways, and clinical significance of LEF1-AS1 in cancer. It is concluded that LEF1-AS1 can serve as a novel biomarker for the diagnosis and prognosis of various tumors, thus deserves further attention in the future. Frontiers Media S.A. 2021-12-20 /pmc/articles/PMC8721001/ /pubmed/34988073 http://dx.doi.org/10.3389/fcell.2021.750084 Text en Copyright © 2021 Zheng, Yu, Zhang, Zhang, Guo and He. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Zheng, Qingyuan
Yu, Xiao
Zhang, Menggang
Zhang, Shuijun
Guo, Wenzhi
He, Yuting
Current Research Progress of the Role of LncRNA LEF1-AS1 in a Variety of Tumors
title Current Research Progress of the Role of LncRNA LEF1-AS1 in a Variety of Tumors
title_full Current Research Progress of the Role of LncRNA LEF1-AS1 in a Variety of Tumors
title_fullStr Current Research Progress of the Role of LncRNA LEF1-AS1 in a Variety of Tumors
title_full_unstemmed Current Research Progress of the Role of LncRNA LEF1-AS1 in a Variety of Tumors
title_short Current Research Progress of the Role of LncRNA LEF1-AS1 in a Variety of Tumors
title_sort current research progress of the role of lncrna lef1-as1 in a variety of tumors
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721001/
https://www.ncbi.nlm.nih.gov/pubmed/34988073
http://dx.doi.org/10.3389/fcell.2021.750084
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