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Targeting Metabolic Pathways of Myeloid Cells Improves Cancer Immunotherapy

Tumor-infiltrating myeloid cells are a prominent pro-tumorigenic immune cell population that limit host anti-tumor immunity and present a significant obstacle for many cancer immunotherapies. Targeting the mechanisms regulating myeloid cell function within the tumor microenvironment may overcome imm...

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Autores principales: Li, Jianying, Bolyard, Chelsea, Xin, Gang, Li, Zihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721007/
https://www.ncbi.nlm.nih.gov/pubmed/34988072
http://dx.doi.org/10.3389/fcell.2021.747863
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author Li, Jianying
Bolyard, Chelsea
Xin, Gang
Li, Zihai
author_facet Li, Jianying
Bolyard, Chelsea
Xin, Gang
Li, Zihai
author_sort Li, Jianying
collection PubMed
description Tumor-infiltrating myeloid cells are a prominent pro-tumorigenic immune cell population that limit host anti-tumor immunity and present a significant obstacle for many cancer immunotherapies. Targeting the mechanisms regulating myeloid cell function within the tumor microenvironment may overcome immunotherapy resistance in some cancers. Recent discoveries in the emerging field of immunometabolism reveal that the metabolic profiles of intratumoral myeloid cells are rewired to adapt to the nutrition-limited tumor microenvironment, and this shapes their pro-tumor phenotypes. Interestingly, metabolic modulation can shift these myeloid cells toward the immune-stimulating anti-tumor phenotype. In this review, we will highlight the roles of specific metabolic pathways in the activation and function of myeloid cells, and discuss the therapeutic value of metabolically reprogramming myeloid cells to augment and improve outcomes with cancer immunotherapy.
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spelling pubmed-87210072022-01-04 Targeting Metabolic Pathways of Myeloid Cells Improves Cancer Immunotherapy Li, Jianying Bolyard, Chelsea Xin, Gang Li, Zihai Front Cell Dev Biol Cell and Developmental Biology Tumor-infiltrating myeloid cells are a prominent pro-tumorigenic immune cell population that limit host anti-tumor immunity and present a significant obstacle for many cancer immunotherapies. Targeting the mechanisms regulating myeloid cell function within the tumor microenvironment may overcome immunotherapy resistance in some cancers. Recent discoveries in the emerging field of immunometabolism reveal that the metabolic profiles of intratumoral myeloid cells are rewired to adapt to the nutrition-limited tumor microenvironment, and this shapes their pro-tumor phenotypes. Interestingly, metabolic modulation can shift these myeloid cells toward the immune-stimulating anti-tumor phenotype. In this review, we will highlight the roles of specific metabolic pathways in the activation and function of myeloid cells, and discuss the therapeutic value of metabolically reprogramming myeloid cells to augment and improve outcomes with cancer immunotherapy. Frontiers Media S.A. 2021-12-20 /pmc/articles/PMC8721007/ /pubmed/34988072 http://dx.doi.org/10.3389/fcell.2021.747863 Text en Copyright © 2021 Li, Bolyard, Xin and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Li, Jianying
Bolyard, Chelsea
Xin, Gang
Li, Zihai
Targeting Metabolic Pathways of Myeloid Cells Improves Cancer Immunotherapy
title Targeting Metabolic Pathways of Myeloid Cells Improves Cancer Immunotherapy
title_full Targeting Metabolic Pathways of Myeloid Cells Improves Cancer Immunotherapy
title_fullStr Targeting Metabolic Pathways of Myeloid Cells Improves Cancer Immunotherapy
title_full_unstemmed Targeting Metabolic Pathways of Myeloid Cells Improves Cancer Immunotherapy
title_short Targeting Metabolic Pathways of Myeloid Cells Improves Cancer Immunotherapy
title_sort targeting metabolic pathways of myeloid cells improves cancer immunotherapy
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721007/
https://www.ncbi.nlm.nih.gov/pubmed/34988072
http://dx.doi.org/10.3389/fcell.2021.747863
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