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Macrophage Polarization and Plasticity in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease that attacks almost every organ. The condition mostly happens to adults but is also found in children, and the latter have the most severe manifestations. Among adults, females, especially non-Caucasian, are mostly affected. Even if the eti...

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Autores principales: Ahamada, Mariame Mohamed, Jia, Yang, Wu, Xiaochuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721097/
https://www.ncbi.nlm.nih.gov/pubmed/34987500
http://dx.doi.org/10.3389/fimmu.2021.734008
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author Ahamada, Mariame Mohamed
Jia, Yang
Wu, Xiaochuan
author_facet Ahamada, Mariame Mohamed
Jia, Yang
Wu, Xiaochuan
author_sort Ahamada, Mariame Mohamed
collection PubMed
description Systemic lupus erythematosus (SLE) is an autoimmune disease that attacks almost every organ. The condition mostly happens to adults but is also found in children, and the latter have the most severe manifestations. Among adults, females, especially non-Caucasian, are mostly affected. Even if the etiology of SLE remains unclear, studies show a close relation between this disease and both genetics and environment. Despite the large number of published articles about SLE, we still do not have a clear picture of its pathogenesis, and no specific drug has been found to treat this condition effectively. The implication of macrophages in SLE development is gaining ground, and studying it could answer these gaps. Indeed, both in vivo and in vitro studies increasingly report a strong link between this disease and macrophages. Hence, this review aims to explore the role of macrophages polarization and plasticity in SLE development. Understanding this role is of paramount importance because in-depth knowledge of the connection between macrophages and this systemic disease could clarify its pathogenesis and provide a foundation for macrophage-centered therapeutic approaches.
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spelling pubmed-87210972022-01-04 Macrophage Polarization and Plasticity in Systemic Lupus Erythematosus Ahamada, Mariame Mohamed Jia, Yang Wu, Xiaochuan Front Immunol Immunology Systemic lupus erythematosus (SLE) is an autoimmune disease that attacks almost every organ. The condition mostly happens to adults but is also found in children, and the latter have the most severe manifestations. Among adults, females, especially non-Caucasian, are mostly affected. Even if the etiology of SLE remains unclear, studies show a close relation between this disease and both genetics and environment. Despite the large number of published articles about SLE, we still do not have a clear picture of its pathogenesis, and no specific drug has been found to treat this condition effectively. The implication of macrophages in SLE development is gaining ground, and studying it could answer these gaps. Indeed, both in vivo and in vitro studies increasingly report a strong link between this disease and macrophages. Hence, this review aims to explore the role of macrophages polarization and plasticity in SLE development. Understanding this role is of paramount importance because in-depth knowledge of the connection between macrophages and this systemic disease could clarify its pathogenesis and provide a foundation for macrophage-centered therapeutic approaches. Frontiers Media S.A. 2021-12-20 /pmc/articles/PMC8721097/ /pubmed/34987500 http://dx.doi.org/10.3389/fimmu.2021.734008 Text en Copyright © 2021 Ahamada, Jia and Wu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ahamada, Mariame Mohamed
Jia, Yang
Wu, Xiaochuan
Macrophage Polarization and Plasticity in Systemic Lupus Erythematosus
title Macrophage Polarization and Plasticity in Systemic Lupus Erythematosus
title_full Macrophage Polarization and Plasticity in Systemic Lupus Erythematosus
title_fullStr Macrophage Polarization and Plasticity in Systemic Lupus Erythematosus
title_full_unstemmed Macrophage Polarization and Plasticity in Systemic Lupus Erythematosus
title_short Macrophage Polarization and Plasticity in Systemic Lupus Erythematosus
title_sort macrophage polarization and plasticity in systemic lupus erythematosus
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721097/
https://www.ncbi.nlm.nih.gov/pubmed/34987500
http://dx.doi.org/10.3389/fimmu.2021.734008
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