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Characterization of Definitive Regulatory B Cell Subsets by Cell Surface Phenotype, Function and Context
Regulatory B cell or “Breg” is a broad term that represents the anti-inflammatory activity of B cells, but does not describe their individual phenotypes, specific mechanisms of regulation or relevant disease contexts. Thus, given the variety of B cell regulatory mechanisms reported in human disease...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721101/ https://www.ncbi.nlm.nih.gov/pubmed/34987513 http://dx.doi.org/10.3389/fimmu.2021.787464 |
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author | Neu, Savannah D. Dittel, Bonnie N. |
author_facet | Neu, Savannah D. Dittel, Bonnie N. |
author_sort | Neu, Savannah D. |
collection | PubMed |
description | Regulatory B cell or “Breg” is a broad term that represents the anti-inflammatory activity of B cells, but does not describe their individual phenotypes, specific mechanisms of regulation or relevant disease contexts. Thus, given the variety of B cell regulatory mechanisms reported in human disease and their animal models, a more thorough and comprehensive identification strategy is needed for tracking and comparing B cell subsets between research groups and in clinical settings. This review summarizes the discovery process and mechanism of action for well-defined regulatory B cell subsets with an emphasis on the mouse model of multiple sclerosis experimental autoimmune encephalomyelitis. We discuss the importance of conducting thorough B cell phenotyping along with mechanistic studies prior to defining a particular subset of B cells as Breg. Since virtually all B cell subsets can exert regulatory activity, it is timely for their definitive identification across studies. |
format | Online Article Text |
id | pubmed-8721101 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87211012022-01-04 Characterization of Definitive Regulatory B Cell Subsets by Cell Surface Phenotype, Function and Context Neu, Savannah D. Dittel, Bonnie N. Front Immunol Immunology Regulatory B cell or “Breg” is a broad term that represents the anti-inflammatory activity of B cells, but does not describe their individual phenotypes, specific mechanisms of regulation or relevant disease contexts. Thus, given the variety of B cell regulatory mechanisms reported in human disease and their animal models, a more thorough and comprehensive identification strategy is needed for tracking and comparing B cell subsets between research groups and in clinical settings. This review summarizes the discovery process and mechanism of action for well-defined regulatory B cell subsets with an emphasis on the mouse model of multiple sclerosis experimental autoimmune encephalomyelitis. We discuss the importance of conducting thorough B cell phenotyping along with mechanistic studies prior to defining a particular subset of B cells as Breg. Since virtually all B cell subsets can exert regulatory activity, it is timely for their definitive identification across studies. Frontiers Media S.A. 2021-12-20 /pmc/articles/PMC8721101/ /pubmed/34987513 http://dx.doi.org/10.3389/fimmu.2021.787464 Text en Copyright © 2021 Neu and Dittel https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Neu, Savannah D. Dittel, Bonnie N. Characterization of Definitive Regulatory B Cell Subsets by Cell Surface Phenotype, Function and Context |
title | Characterization of Definitive Regulatory B Cell Subsets by Cell Surface Phenotype, Function and Context |
title_full | Characterization of Definitive Regulatory B Cell Subsets by Cell Surface Phenotype, Function and Context |
title_fullStr | Characterization of Definitive Regulatory B Cell Subsets by Cell Surface Phenotype, Function and Context |
title_full_unstemmed | Characterization of Definitive Regulatory B Cell Subsets by Cell Surface Phenotype, Function and Context |
title_short | Characterization of Definitive Regulatory B Cell Subsets by Cell Surface Phenotype, Function and Context |
title_sort | characterization of definitive regulatory b cell subsets by cell surface phenotype, function and context |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721101/ https://www.ncbi.nlm.nih.gov/pubmed/34987513 http://dx.doi.org/10.3389/fimmu.2021.787464 |
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