Cargando…

Engineering Electrospun Nanofibers for the Treatment of Oral Diseases

With the increase of consumption of high-sugar foods, beverages, tobacco, and alcohol, the incidence rate of oral diseases has been increasing year by year. Statistics showed that the prevalence of oral diseases such as dental caries, dental pulpal disease, and periodontal disease has reached as hig...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yuanfei, Liu, Yingnan, Zhang, Xiaopei, Liu, Na, Yu, Xixi, Gao, Meihua, Wang, Wanchun, Wu, Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721107/
https://www.ncbi.nlm.nih.gov/pubmed/34988063
http://dx.doi.org/10.3389/fchem.2021.797523
_version_ 1784625264577216512
author Wang, Yuanfei
Liu, Yingnan
Zhang, Xiaopei
Liu, Na
Yu, Xixi
Gao, Meihua
Wang, Wanchun
Wu, Tong
author_facet Wang, Yuanfei
Liu, Yingnan
Zhang, Xiaopei
Liu, Na
Yu, Xixi
Gao, Meihua
Wang, Wanchun
Wu, Tong
author_sort Wang, Yuanfei
collection PubMed
description With the increase of consumption of high-sugar foods, beverages, tobacco, and alcohol, the incidence rate of oral diseases has been increasing year by year. Statistics showed that the prevalence of oral diseases such as dental caries, dental pulpal disease, and periodontal disease has reached as high as 97% in 2015 in China. It is thus urgent to develop functional materials or products for the treatment of oral diseases. Electrospinning has been a widely used technology that is capable of utilizing polymer solution to generate micro/nano fibers under an appropriate high voltage condition. Owing to their excellent structures and biological performances, materials prepared by electrospinning technology have been used for a wide range of oral-related applications, such as tissue restoration, controlled drug release, anti-cancer, etc. In this regard, this article reviews the application and progress of electrospun nanofibers to various oral diseases in recent years. Firstly, engineering strategies of a variety of nanofiber structures together with their resultant functions will be introduced. Then, biological functions of electrospun nanofibers as well as their applications in the treatment of oral diseases are summarized and demonstrated. Finally, the development viewpoint of functional nanofibers is prospected, which is expected to lay the foundation and propose the direction for further clinical application.
format Online
Article
Text
id pubmed-8721107
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-87211072022-01-04 Engineering Electrospun Nanofibers for the Treatment of Oral Diseases Wang, Yuanfei Liu, Yingnan Zhang, Xiaopei Liu, Na Yu, Xixi Gao, Meihua Wang, Wanchun Wu, Tong Front Chem Chemistry With the increase of consumption of high-sugar foods, beverages, tobacco, and alcohol, the incidence rate of oral diseases has been increasing year by year. Statistics showed that the prevalence of oral diseases such as dental caries, dental pulpal disease, and periodontal disease has reached as high as 97% in 2015 in China. It is thus urgent to develop functional materials or products for the treatment of oral diseases. Electrospinning has been a widely used technology that is capable of utilizing polymer solution to generate micro/nano fibers under an appropriate high voltage condition. Owing to their excellent structures and biological performances, materials prepared by electrospinning technology have been used for a wide range of oral-related applications, such as tissue restoration, controlled drug release, anti-cancer, etc. In this regard, this article reviews the application and progress of electrospun nanofibers to various oral diseases in recent years. Firstly, engineering strategies of a variety of nanofiber structures together with their resultant functions will be introduced. Then, biological functions of electrospun nanofibers as well as their applications in the treatment of oral diseases are summarized and demonstrated. Finally, the development viewpoint of functional nanofibers is prospected, which is expected to lay the foundation and propose the direction for further clinical application. Frontiers Media S.A. 2021-12-20 /pmc/articles/PMC8721107/ /pubmed/34988063 http://dx.doi.org/10.3389/fchem.2021.797523 Text en Copyright © 2021 Wang, Liu, Zhang, Liu, Yu, Gao, Wang and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Wang, Yuanfei
Liu, Yingnan
Zhang, Xiaopei
Liu, Na
Yu, Xixi
Gao, Meihua
Wang, Wanchun
Wu, Tong
Engineering Electrospun Nanofibers for the Treatment of Oral Diseases
title Engineering Electrospun Nanofibers for the Treatment of Oral Diseases
title_full Engineering Electrospun Nanofibers for the Treatment of Oral Diseases
title_fullStr Engineering Electrospun Nanofibers for the Treatment of Oral Diseases
title_full_unstemmed Engineering Electrospun Nanofibers for the Treatment of Oral Diseases
title_short Engineering Electrospun Nanofibers for the Treatment of Oral Diseases
title_sort engineering electrospun nanofibers for the treatment of oral diseases
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721107/
https://www.ncbi.nlm.nih.gov/pubmed/34988063
http://dx.doi.org/10.3389/fchem.2021.797523
work_keys_str_mv AT wangyuanfei engineeringelectrospunnanofibersforthetreatmentoforaldiseases
AT liuyingnan engineeringelectrospunnanofibersforthetreatmentoforaldiseases
AT zhangxiaopei engineeringelectrospunnanofibersforthetreatmentoforaldiseases
AT liuna engineeringelectrospunnanofibersforthetreatmentoforaldiseases
AT yuxixi engineeringelectrospunnanofibersforthetreatmentoforaldiseases
AT gaomeihua engineeringelectrospunnanofibersforthetreatmentoforaldiseases
AT wangwanchun engineeringelectrospunnanofibersforthetreatmentoforaldiseases
AT wutong engineeringelectrospunnanofibersforthetreatmentoforaldiseases