Cargando…

Enhanced Oral Bioavailability of Epalrestat SBE(7)-β-CD Complex Loaded Chitosan Nanoparticles: Preparation, Characterization and in-vivo Pharmacokinetic Evaluation

BACKGROUND: Epalrestat (EPL) is a carboxylic acid derivative with poor aqueous solubility and its pharmacokinetic features are not fully defined. PURPOSE: Current research aimed to fabricate inclusion complexation of EPL with SBE(7) β-CD (IC) and EPL/SBE(7) β-CD CS NPs (NP). METHODS: EPL was complex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alvi, Zunaira, Akhtar, Muhammad, Mahmood, Arshad, ur-Rahman, Nisar, Nazir, Imran, Sadaquat, Hadia, Ijaz, Muhammad, Syed, Shahzada Khurram, Waqas, Muhammad Khurram, Wang, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721161/ https://www.ncbi.nlm.nih.gov/pubmed/35002232 http://dx.doi.org/10.2147/IJN.S339857

Ejemplares similares

Utilization of Gelling Polymer to Formulate Nanoparticles Loaded with Epalrestat-Cyclodextrin Inclusion Complex: Formulation, Characterization, In-Silico Modelling and In-Vivo Toxicity Evaluation
por: Alvi, Zunaira, et al.
Publicado: (2021)

Raloxifene/SBE-β-CD Inclusion Complexes Formulated into Nanoparticles with Chitosan to Overcome the Absorption Barrier for Bioavailability Enhancement
por: Wang, Zaihua, et al.
Publicado: (2018)

Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives
por: Edis, Zehra, et al.
Publicado: (2021)

An Empirical Study on Diabetes Depression over Distress Evaluation Using Diagnosis Statistical Manual and Chi-Square Method
por: Noman, Sohail M., et al.
Publicado: (2021)

Berberine nanoparticles with enhanced in vitro bioavailability: characterization and antimicrobial activity
por: Sahibzada, Muhammad Umar Khayam, et al.
Publicado: (2018)

Enhanced Intestinal Permeability of Cefixime by Self-Emulsifying Drug Delivery System: In-Vitro and Ex-Vivo Characterization
por: Mahmood, Arshad, et al.
Publicado: (2023)

Fabrication, characterization and in vitro evaluation of silibinin nanoparticles: an attempt to enhance its oral bioavailability
por: Sahibzada, Muhammad Umar Khayam, et al.
Publicado: (2017)

A Putative Gene sbe3-rs for Resistant Starch Mutated from SBE3 for Starch Branching Enzyme in Rice (Oryza sativa L.)
por: Yang, Ruifang, et al.
Publicado: (2012)

A National Survey to Assess the COVID-19 Vaccine-Related Conspiracy Beliefs, Acceptability, Preference, and Willingness to Pay among the General Population of Pakistan
por: Arshad, Muhammad Subhan, et al.
Publicado: (2021)

Spectrum of Clinical Presentation of Celiac Disease in Pediatric Population
por: ., Imran, et al.
Publicado: (2021)

N-Acetylcysteine overcomes epalrestat-mediated increase of toxic 4-hydroxy-2-nonenal and potentiates the anti-arthritic effect of epalrestat in AIA model
por: Wang, Linna, et al.
Publicado: (2023)

Incidence of retinopathy in chronic hepatitis C patients treated with pegylated interferon alpha 2a and ribavirin combination therapy
por: Kashif, Muhammad, et al.
Publicado: (2015)

Transient Bacteremia Due to Suction Abortion: Implications for SBE Antibiotic Prophylaxis
por: Ritvo, Rachel, et al.
Publicado: (1977)

Pharmacokinetic variables of medium molecular weight cross linked chitosan nanoparticles to enhance the bioavailability of 5-fluorouracil and reduce the acute oral toxicity
por: Sethi, Aisha, et al.
Publicado: (2021)

Comparison of blood loss between intra-articular and intra-venous administration of tranexamic acid in primary total knee arthroplasty
por: Amin, Muhammad Suhail, et al.
Publicado: (2020)

Jasminum sambac: A Potential Candidate for Drug Development to Cure Cardiovascular Ailments
por: Khan, Imran Ahmad, et al.
Publicado: (2021)

Epalrestat, an aldose reductase inhibitor, in diabetic neuropathy: An Indian perspective
por: Sharma, S. R., et al.
Publicado: (2008)

Synthesis and Characterization of Carboxymethyl Chitosan Nanosponges with Cyclodextrin Blends for Drug Solubility Improvement
por: Rizvi, Syeda Sadia Batool, et al.
Publicado: (2022)

Metered Dose Inhaler Technique: A Priority Catch for Physicians
por: Ahmed, Muhammad, et al.
Publicado: (2020)

First theoretical framework for highly efficient photovoltaic parameters by structural modification with benzothiophene-incorporated acceptors in dithiophene based chromophores
por: Khalid, Muhammad, et al.
Publicado: (2022)

Inferiorly based thigh flap for reconstruction of defects around the knee joint
por: Akhtar, Md. Sohaib, et al.
Publicado: (2014)

Frequency of Delayed Diagnosis of Oral Squamous Cell Carcinoma in Pakistan
por: Naseer, Rabia, et al.
Publicado: (2016)

Fabrication of Tamarindus indica seeds extract loaded-cream for photo-aged skin: Visioscan(®) studies
por: Waqas, Muhammad Khurram, et al.
Publicado: (2017)

Efficacy, safety, and tolerability of Epalrestat compared to Methylcobalamine in patients with diabetic neuropathy
por: Maladkar, Manish, et al.
Publicado: (2009)

Epalrestat tetrahydrofuran monosolvate: crystal structure and phase transition
por: Umeda, Daiki, et al.
Publicado: (2017)

Investigating the Psychology of Financial Markets During COVID-19 Era: A Case Study of the US and European Markets
por: Shehzad, Khurram, et al.
Publicado: (2020)

Highly Responsive Chitosan-Co-Poly (MAA) Nanomatrices through Cross-Linking Polymerization for Solubility Improvement
por: Saleem, Anam, et al.
Publicado: (2022)

Fabrication and Characterization of Ag–Sr-Substituted Hydroxyapatite/Chitosan Coatings Deposited via Electrophoretic Deposition: A Design of Experiment Study
por: Saleem, Osama, et al.
Publicado: (2020)

Amelioration of Ovalbumin-Induced Allergic Asthma by Juglans regia via Downregulation of Inflammatory Cytokines and Upregulation of Aquaporin-1 and Aquaporin-5 in Mice
por: Sharif, Mariam, et al.
Publicado: (2022)

SBE13, a newly identified inhibitor of inactive polo-like kinase 1
por: Keppner, Sarah, et al.
Publicado: (2010)

Synthesis of an amantadine-based novel Schiff base and its transition metal complexes as potential ALP, α-amylase, and α-glucosidase inhibitors
por: Ajaz, Aliya, et al.
Publicado: (2023)

Development and characterization of niosomal gel of fusidic acid: in-vitro and ex-vivo approaches
por: Waqas, Muhammad Khurram, et al.
Publicado: (2022)

Epalrestat increases intracellular glutathione levels in Schwann cells through transcription regulation()
por: Sato, Keisuke, et al.
Publicado: (2013)

Amelioration of Bleomycin-induced Pulmonary Fibrosis of Rats by an Aldose Reductase Inhibitor, Epalrestat
por: Li, Xianwei, et al.
Publicado: (2015)

Formulation and Characterization of Epalrestat-Loaded Polysorbate 60 Cationic Niosomes for Ocular Delivery
por: Kattar, Axel, et al.
Publicado: (2023)

Emerging IoT Applications in Sustainable Smart Cities for COVID-19: Network Security and Data Preservation Challenges with Future Directions
por: Adil, Muhammad, et al.
Publicado: (2021)

Intravenous Pharmacokinetics, Local Tolerability, and Hemolysis of an SBE7-β-Cyclodextrin Formulation of the Neurokinin-1 Receptor Antagonist Vestipitant
por: Brigandi, Richard A, et al.
Publicado: (2015)

Importance of telecommunications in the times of COVID-19
por: Khan, Muhammad Khurram
Publicado: (2021)

Technology and telecommunications: a panacea in the COVID-19 crisis
por: Khan, Muhammad Khurram
Publicado: (2022)

Bioactive Steroids and Saponins of the Genus Trillium
por: Ur Rahman, Shafiq, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_8vhbrpmhh6097fbsmb1141l5qj