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Enhanced Oral Bioavailability of Epalrestat SBE(7)-β-CD Complex Loaded Chitosan Nanoparticles: Preparation, Characterization and in-vivo Pharmacokinetic Evaluation

BACKGROUND: Epalrestat (EPL) is a carboxylic acid derivative with poor aqueous solubility and its pharmacokinetic features are not fully defined. PURPOSE: Current research aimed to fabricate inclusion complexation of EPL with SBE(7) β-CD (IC) and EPL/SBE(7) β-CD CS NPs (NP). METHODS: EPL was complex...

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Detalles Bibliográficos
Autores principales:	Alvi, Zunaira, Akhtar, Muhammad, Mahmood, Arshad, ur-Rahman, Nisar, Nazir, Imran, Sadaquat, Hadia, Ijaz, Muhammad, Syed, Shahzada Khurram, Waqas, Muhammad Khurram, Wang, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721161/ https://www.ncbi.nlm.nih.gov/pubmed/35002232 http://dx.doi.org/10.2147/IJN.S339857

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