Activation and Evasion of RLR Signaling by DNA Virus Infection

Antiviral innate immune response triggered by nucleic acid recognition plays an extremely important role in controlling viral infections. The initiation of antiviral immune response against RNA viruses through ligand recognition of retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) was ext...

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Detalles Bibliográficos
Autores principales: Jia, Junli, Fu, Jiangan, Tang, Huamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721196/
https://www.ncbi.nlm.nih.gov/pubmed/34987495
http://dx.doi.org/10.3389/fmicb.2021.804511
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author Jia, Junli
Fu, Jiangan
Tang, Huamin
author_facet Jia, Junli
Fu, Jiangan
Tang, Huamin
author_sort Jia, Junli
collection PubMed
description Antiviral innate immune response triggered by nucleic acid recognition plays an extremely important role in controlling viral infections. The initiation of antiviral immune response against RNA viruses through ligand recognition of retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) was extensively studied. RLR’s role in DNA virus infection, which is less known, is increasing attention. Here, we review the research progress of the ligand recognition of RLRs during the DNA virus infection process and the viral evasion mechanism from host immune responses.
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spelling pubmed-87211962022-01-04 Activation and Evasion of RLR Signaling by DNA Virus Infection Jia, Junli Fu, Jiangan Tang, Huamin Front Microbiol Microbiology Antiviral innate immune response triggered by nucleic acid recognition plays an extremely important role in controlling viral infections. The initiation of antiviral immune response against RNA viruses through ligand recognition of retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) was extensively studied. RLR’s role in DNA virus infection, which is less known, is increasing attention. Here, we review the research progress of the ligand recognition of RLRs during the DNA virus infection process and the viral evasion mechanism from host immune responses. Frontiers Media S.A. 2021-12-20 /pmc/articles/PMC8721196/ /pubmed/34987495 http://dx.doi.org/10.3389/fmicb.2021.804511 Text en Copyright © 2021 Jia, Fu and Tang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Jia, Junli
Fu, Jiangan
Tang, Huamin
Activation and Evasion of RLR Signaling by DNA Virus Infection
title Activation and Evasion of RLR Signaling by DNA Virus Infection
title_full Activation and Evasion of RLR Signaling by DNA Virus Infection
title_fullStr Activation and Evasion of RLR Signaling by DNA Virus Infection
title_full_unstemmed Activation and Evasion of RLR Signaling by DNA Virus Infection
title_short Activation and Evasion of RLR Signaling by DNA Virus Infection
title_sort activation and evasion of rlr signaling by dna virus infection
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721196/
https://www.ncbi.nlm.nih.gov/pubmed/34987495
http://dx.doi.org/10.3389/fmicb.2021.804511
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AT fujiangan activationandevasionofrlrsignalingbydnavirusinfection
AT tanghuamin activationandevasionofrlrsignalingbydnavirusinfection

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