Spred2 controls the severity of Concanavalin A-induced liver damage by limiting interferon-gamma production by CD4(+) and CD8(+) T cells

INTRODUCTION: Mitogen-activated protein kinases (MAPKs) are involved in T cell-mediated liver damage. However, the inhibitory mechanism(s) that controls T cell-mediated liver damage remains unknown. OBJECTIVES: We investigated whether Spred2 (Sprouty-related, EVH1 domain-containing protein 2) that n...

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Detalles Bibliográficos
Autores principales: Sun, Cuiming, Fujisawa, Masayoshi, Ohara, Toshiaki, Liu, Qiuying, Cao, Chen, Yang, Xu, Yoshimura, Teizo, Kunkel, Steven L., Matsukawa, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721245/
https://www.ncbi.nlm.nih.gov/pubmed/35003795
http://dx.doi.org/10.1016/j.jare.2021.03.014

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