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The demographic, clinical, and medical manifestations of pulmonary thromboembolism development in COVID-19

BACKGROUND: Since the emergence of coronavirus disease 2019 (COVID-19), various clinical manifestations ranging from asymptomatic to severe, life-threatening courses have been presented. It is well known that COVID-19 patients are at an increased risk of pulmonary thromboembolism (PTE) development;...

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Autores principales: Sadeghi, Somayeh, Nasirian, Maryam, Keivany, Elaheh, Nasri, Peiman, Mirenayat, Maryam Sadat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721446/
https://www.ncbi.nlm.nih.gov/pubmed/34880142
http://dx.doi.org/10.5045/br.2021.2021131
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author Sadeghi, Somayeh
Nasirian, Maryam
Keivany, Elaheh
Nasri, Peiman
Mirenayat, Maryam Sadat
author_facet Sadeghi, Somayeh
Nasirian, Maryam
Keivany, Elaheh
Nasri, Peiman
Mirenayat, Maryam Sadat
author_sort Sadeghi, Somayeh
collection PubMed
description BACKGROUND: Since the emergence of coronavirus disease 2019 (COVID-19), various clinical manifestations ranging from asymptomatic to severe, life-threatening courses have been presented. It is well known that COVID-19 patients are at an increased risk of pulmonary thromboembolism (PTE) development; however, the associated demographic, medical, and clinical factors for developing PTE remain unknown. The current study aimed to assess the characteristics of patients with PTE. METHODS: This case-control study was derived from an ongoing population-based investigation of hospitalized patients with COVID-19 pneumonia. The case group included 99 patients with PTE confirmed by computed tomography pulmonary angiography (CTPA), and the controls (N=132) were age-matched patients selected from the PTE-suspected patients with a negative CTPA. The demographic, medical, and clinical characteristics of the study population were entered into the study checklist and compared. A logistic regression test was used to determine the factors associated with PTE development. RESULTS: Among the 13,099 admitted patients, 690 (5.26%) were suspected of having PTE according to their clinical manifestations. CTPA was performed for suspected cases, and PTE was confirmed in 132 patients (19.13%). Logistic regression assessments revealed that male gender (OR, 2.39; 95%CI, 1.38‒4.13), decreased oxygen saturation (OR, 2.33; 95%CI, 1.27‒4.26), and lower hemoglobin (OR, 0.83, 0.95), and albumin (OR, 0.31; 95%CI, 0.18‒0.53) levels were associated with PTE development. CONCLUSION: PTE was confirmed in one-fifth of suspected patients who underwent CTPA imaging. Male sex, decreased oxygen saturation, and lower levels of hemoglobin and albumin were independent predictors of PTE in patients with COVID-19 pneumonia.
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spelling pubmed-87214462022-01-11 The demographic, clinical, and medical manifestations of pulmonary thromboembolism development in COVID-19 Sadeghi, Somayeh Nasirian, Maryam Keivany, Elaheh Nasri, Peiman Mirenayat, Maryam Sadat Blood Res Original Article BACKGROUND: Since the emergence of coronavirus disease 2019 (COVID-19), various clinical manifestations ranging from asymptomatic to severe, life-threatening courses have been presented. It is well known that COVID-19 patients are at an increased risk of pulmonary thromboembolism (PTE) development; however, the associated demographic, medical, and clinical factors for developing PTE remain unknown. The current study aimed to assess the characteristics of patients with PTE. METHODS: This case-control study was derived from an ongoing population-based investigation of hospitalized patients with COVID-19 pneumonia. The case group included 99 patients with PTE confirmed by computed tomography pulmonary angiography (CTPA), and the controls (N=132) were age-matched patients selected from the PTE-suspected patients with a negative CTPA. The demographic, medical, and clinical characteristics of the study population were entered into the study checklist and compared. A logistic regression test was used to determine the factors associated with PTE development. RESULTS: Among the 13,099 admitted patients, 690 (5.26%) were suspected of having PTE according to their clinical manifestations. CTPA was performed for suspected cases, and PTE was confirmed in 132 patients (19.13%). Logistic regression assessments revealed that male gender (OR, 2.39; 95%CI, 1.38‒4.13), decreased oxygen saturation (OR, 2.33; 95%CI, 1.27‒4.26), and lower hemoglobin (OR, 0.83, 0.95), and albumin (OR, 0.31; 95%CI, 0.18‒0.53) levels were associated with PTE development. CONCLUSION: PTE was confirmed in one-fifth of suspected patients who underwent CTPA imaging. Male sex, decreased oxygen saturation, and lower levels of hemoglobin and albumin were independent predictors of PTE in patients with COVID-19 pneumonia. Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2021-12-31 2021-12-31 /pmc/articles/PMC8721446/ /pubmed/34880142 http://dx.doi.org/10.5045/br.2021.2021131 Text en © 2021 Korean Society of Hematology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sadeghi, Somayeh
Nasirian, Maryam
Keivany, Elaheh
Nasri, Peiman
Mirenayat, Maryam Sadat
The demographic, clinical, and medical manifestations of pulmonary thromboembolism development in COVID-19
title The demographic, clinical, and medical manifestations of pulmonary thromboembolism development in COVID-19
title_full The demographic, clinical, and medical manifestations of pulmonary thromboembolism development in COVID-19
title_fullStr The demographic, clinical, and medical manifestations of pulmonary thromboembolism development in COVID-19
title_full_unstemmed The demographic, clinical, and medical manifestations of pulmonary thromboembolism development in COVID-19
title_short The demographic, clinical, and medical manifestations of pulmonary thromboembolism development in COVID-19
title_sort demographic, clinical, and medical manifestations of pulmonary thromboembolism development in covid-19
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721446/
https://www.ncbi.nlm.nih.gov/pubmed/34880142
http://dx.doi.org/10.5045/br.2021.2021131
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