Challenges of Managing Multiple Myeloma Patients with Sickle Cell Disease: A Case Report and Review of Literature

Patient: Male, 70-year-old Final Diagnosis: Sepsis Symptoms: Painful bone crises and increasing shortness of breath Medication: — Clinical Procedure: — Specialty: Hematology OBJECTIVE: Rare coexistence of disease or pathology BACKGROUND: A congenital hemolytic anemia, sickle cell disease can present with various clinical findings. Sickle cell disease is typically a disease of younger people and multiple myeloma typically occurs in older individuals. Multiple myeloma is rare among patients with sickle cell disease. Both multiple myeloma and sickle cell disease can cause various types of organ damage by different mechanisms. CASE REPORT: We report a case of a patient who was born with sickle cell disease and presented with multiple myeloma later in life. Although he responded to anti-myeloma therapy, he died of hepatic and renal failure from complications of both multiple myeloma and sickle cell disease. CONCLUSIONS: We discuss the complexity involved and present a review of the literature on managing multiple myeloma in relation to hepatic iron overload and end-stage renal disease in the setting of multiple myeloma and underlying sickle cell disease.