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Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic elongation factor 2 kinase (eEF2K)

BACKGROUND: Dravet Syndrome is a severe childhood pharmaco-resistant epileptic disorder mainly caused by mutations in the SCN1A gene, which encodes for the α1 subunit of the type I voltage-gated sodium channel (Na(V)1.1), that causes imbalance between excitation and inhibition in the brain. We recen...

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Detalles Bibliográficos
Autores principales:	Beretta, Stefania, Gritti, Laura, Ponzoni, Luisa, Scalmani, Paolo, Mantegazza, Massimo, Sala, Mariaelvina, Verpelli, Chiara, Sala, Carlo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722032/ https://www.ncbi.nlm.nih.gov/pubmed/34980259 http://dx.doi.org/10.1186/s13229-021-00484-0

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